Q2T0U7 (SUCC_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	BTH_I0646

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558		PRO_1000082047
Regions
	Domain	9 – 244	236	ATP-grasp
	Nucleotide binding	35 – 108	74	ATP By similarity
Sites
	Metal binding	197	1	Magnesium or manganese By similarity
	Metal binding	199	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2T0U7 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: BB4F3EA47E4573B6	FASTA	388	41,259
	10 20 30 40 50 60 MKIHEYQGKE ILRKFGVAVP RGKPAFSVDE AVKVAEELGG PVWVVKAQIH AGGRGKGGGV 70 80 90 100 110 120 KVAKSLDQVR EYANQILGMQ LKTHQTGPEG QKVNRLLIEE GADIKKELYV GIVIDRVSQK 130 140 150 160 170 180 VVVMASSEGG MDIEEVAEKT PEAIHKVAVE PSTGLQDAEA DDLAKKIGVP DASIPQAREI 190 200 210 220 230 240 LKGLYKSFWE TDASLAEINP LVLTGDGKVI ALDAKFNFDS NALFRHPEIV AYRDLDEEDP 250 260 270 280 290 300 AEIEASKFDL AYISLDGNIG CLVNGAGLAM ATMDTIKLFG GEPANFLDVG GGATTEKVTE 310 320 330 340 350 360 AFKLMLKNPG LKAILVNIFG GIMRCDVIAE GVIAGSKAVN LNVPLVVRMK GTNEDLGKKM 370 380 LAESGLPIIS ADSMEEAAQK VVAAAAGK

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC38975.1.
RefSeq	YP_441202.1. NC_007651.1.
3D structure databases
HSSP	HSSP built from PDB template 2FP4 based on UniProtKB P53590.
ProteinModelPortal	Q2T0U7.
SMR	Q2T0U7. Positions 1-384.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2T0U7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3848407.
GenomeReviews	Gene locus BTH_I0646 in contig CP000086_GR.
KEGG	bte:BTH_I0646.
PATRIC	19304057. VBIBurTha36512_3345.
TIGR	BTH_I0646.
Phylogenomic databases
eggNOG	COG0045.
HOGENOM	HBG315432.
OMA	KKELYVS.
ProtClustDB	PRK00696.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I0646-MONOMER.
Family and domain databases
HAMAP	MF_00558. Succ_CoA_beta. [Tree]
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KO	K01903.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001554. SucCS_beta. 1 hit.
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01016. SucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_BURTA

Accession

Primary (citable) accession number: Q2T0U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program