Reviewed, UniProtKB/Swiss-Prot Q2T0N2 (KYNB_BURTA)

Names and origin

Protein names

Recommended name:
    Kynurenine formamidase
      Short name=KFA
    EC=3.5.1.9
Alternative name(s):
    N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BTH_I0711

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362117

Sequences

	Sequence		Length	Mass (Da)
	Q2T0N2-1 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: B35793CA8DBD3885	FASTA	213	22,678
	10 20 30 40 50 60 MDTIWDISPP IAPATPVWPG DTPVGIERVW RIEAGSPVNV ARITLSPHTG AHADAPLHYD 70 80 90 100 110 120 AHGAPIGAVP LDAYLGRCRV IHCIGAHPVV SPDDVRAALA DAPPRVLLRT YGQAPQRAWD 130 140 150 160 170 180 SAFCAVAPQT IDLLAAHGVR LVGIDTPSLD PQESKTMDAH RRIRAHGMAI LEGLVLDEIA 190 200 210 AGDYELIALP LKFATLDASP VRAVLRALPD APR

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000086 Genomic DNA. Translation: ABC37937.1. Different initiation.
RefSeq	YP_441267.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2T0N2.
Genome annotation databases
GeneID	3848711.
GenomeReviews	Gene locus BTH_I0711 in contig CP000086_GR.
KEGG	bte:BTH_I0711.
TIGR	BTH_I0711.
Phylogenomic databases
HOGENOM	Q2T0N2.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I0711-MON.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURTA

Accession

Primary (citable) accession number: Q2T0N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	September 1, 2009
This is version 18 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)