Q2T0N2 (KYNB_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BTH_I0711

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.
Sequence caution	The sequence ABC37937.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362117

Sequences

	Sequence		Length	Mass (Da)
	Q2T0N2 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: B35793CA8DBD3885	FASTA	213	22,678
	10 20 30 40 50 60 MDTIWDISPP IAPATPVWPG DTPVGIERVW RIEAGSPVNV ARITLSPHTG AHADAPLHYD 70 80 90 100 110 120 AHGAPIGAVP LDAYLGRCRV IHCIGAHPVV SPDDVRAALA DAPPRVLLRT YGQAPQRAWD 130 140 150 160 170 180 SAFCAVAPQT IDLLAAHGVR LVGIDTPSLD PQESKTMDAH RRIRAHGMAI LEGLVLDEIA 190 200 210 AGDYELIALP LKFATLDASP VRAVLRALPD APR

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC37937.1. Different initiation.
RefSeq	YP_441267.1. NC_007651.1.
3D structure databases
ProteinModelPortal	Q2T0N2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2T0N2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3848711.
GenomeReviews	Gene locus BTH_I0711 in contig CP000086_GR.
KEGG	bte:BTH_I0711.
PATRIC	19304204. VBIBurTha36512_3418.
TIGR	BTH_I0711.
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
ProtClustDB	CLSK930430.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I0711-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURTA

Accession

Primary (citable) accession number: Q2T0N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 32 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program