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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi389 – 396ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:BTH_I0985
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome I

Subcellular locationi

Q2SZW0:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei292 – 312HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716191 – 596Lipid A export ATP-binding/permease protein MsbAAdd BLAST596

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2SZW0.
SMRiQ2SZW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 321ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini353 – 589ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SZW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKPTLSKP IGGQDASSPA VVMRRLWPYV KPLVWVLVAG VLAMAAVAAT
60 70 80 90 100
EAGIPALLKP LLDHGFGSKG DMTTKLYVPA AVVGLALARA IAQYASGYLL
110 120 130 140 150
QYVSNRILLD LRIQMFERMI HTGVSFFQRE TASTVINAVV FEVNQVLSVL
160 170 180 190 200
MGVMITLVRD SLTVVFLLGY LFYLNWRLTL IVAILLPCIG WLVGKINRRL
210 220 230 240 250
RRLNREHQTL TNQLAYIVEE TVGGYKVVKV HNGESYEIGR FNELSRKLRG
260 270 280 290 300
YSMRMTVSGG LAQPLTQFLA SIALAVVLTI AVVQSSNDQT TVGGFVAFVT
310 320 330 340 350
AMLLIISPLK HLMDVNQPLQ RGMTAAELIF GLIDEPREPE GGGKPLARAS
360 370 380 390 400
GAIEFSHVSF SYGISRDGRQ TLDDVSFTVA PGEMVALAGP SGSGKTTLVN
410 420 430 440 450
LLPRFFDPSS GTVRVDGVAL PEYSLHDLRN QIAMVSQDVV LFNDTIAANV
460 470 480 490 500
AYGQTPERDG VEAALRAANL WETVTAMPDG IDTLVGDNGM RLSGGQRQRL
510 520 530 540 550
AIARAIYKDA PILILDEATS ALDSESERHV QAALETLMKG RTTLVIAHRL
560 570 580 590
STIERADRIL VLEGGKIVES GSHRELLEQG GLYAHLHRIQ FQQDAG
Length:596
Mass (Da):64,783
Last modified:January 24, 2006 - v1
Checksum:i73EC8425AEBF99D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC39003.1.
RefSeqiWP_009892328.1. NZ_CM000438.1.

Genome annotation databases

EnsemblBacteriaiABC39003; ABC39003; BTH_I0985.
KEGGibte:BTH_I0985.

Similar proteinsi

Entry informationi

Entry nameiMSBA_BURTA
AccessioniPrimary (citable) accession number: Q2SZW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 24, 2006
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families