Reviewed, UniProtKB/Swiss-Prot Q2SZP7 (PSD_BURTA)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BTH_I1048

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000262197
	Chain	182 – 216	35	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000262198
Sites
	Site	181 – 182	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	182	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SZP7-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 1A4ACD05EA1ABE43	FASTA	216	23,522
	10 20 30 40 50 60 MNYPHPIIAR EGWPFIAIAA VVALLIHAVG GFGLAWPFWL LLVFVVQFFR DPPRAIPTQA 70 80 90 100 110 120 NAVLCPADGR IVAVETAHDP YANREALKIS VFMNVFNVHS QRSPVDGAVQ KVEYFPGAFL 130 140 150 160 170 180 NAALDKASAE NERNAVVIQT GSGHTVTAVQ IAGLVARRIL CYVRAGEPLS RGQRYGFIRF 190 200 210 GSRVDVYLPK GSRARVSIGE KVSASSTILA ELPEQQ

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000086 Genomic DNA. Translation: ABC36670.1.
RefSeq	YP_441602.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3847318.
GenomeReviews	Gene locus BTH_I1048 in contig CP000086_GR.
KEGG	bte:BTH_I1048.
TIGR	BTH_I1048.
Phylogenomic databases
HOGENOM	Q2SZP7.
OMA	Q2SZP7. DKASEDN.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I1048-MON.
Family and domain databases
HAMAP	MF_00664. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BURTA

Accession

Primary (citable) accession number: Q2SZP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)