Q2SZG8 (COAE_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	BTH_I1133

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity HAMAP MF_00376.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dephospho-CoA kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000243270
Regions
	Domain	3 – 201	199	DPCK
	Nucleotide binding	8 – 15	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2SZG8 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: D07A34CAAD90DB88	FASTA	203	21,731
	10 20 30 40 50 60 MFSVGLTGGI GSGKTTVSNL FGALGATIVD TDLIAHRITA PHGLAMPFIE REFGAQFVAA 70 80 90 100 110 120 DGSLDRAKMR ALIFSDESAR KRLEAITHPL IREETEREAG AAHGAYVVFV VPLLVESGTW 130 140 150 160 170 180 EARVDRVLVV DCDVETQIAR VMSRNGFARE QVEAIVARQA SRDARLAAAD DVIVNDNASL 190 200 DELAAEVAAL HQRYLGYAAA APN

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC39050.1.
RefSeq	YP_441681.1. NC_007651.1.
3D structure databases
ProteinModelPortal	Q2SZG8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SZG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3847692.
GenomeReviews	Gene locus BTH_I1133 in contig CP000086_GR.
KEGG	bte:BTH_I1133.
PATRIC	19305158. VBIBurTha36512_3889.
TIGR	BTH_I1133.
Phylogenomic databases
eggNOG	COG0237.
HOGENOM	HBG650290.
OMA	YVIMVVP.
ProtClustDB	PRK00081.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I1133-MONOMER.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
KO	K00859.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_BURTA

Accession

Primary (citable) accession number: Q2SZG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program