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Protein

Catalase-peroxidase

Gene

katG

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi259 – 2591Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-1282-MONOMER.

Protein family/group databases

PeroxiBasei3663. BthCP01_E264.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:BTH_I1282
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Catalase-peroxidasePRO_0000354751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2SZ20.
SMRiQ2SZ20. Positions 14-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SZ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEAKCPFH HAAGNGTSNR DWWPDQLDLS ALHRHSSLSD PMDRDFNYAQ
60 70 80 90 100
AFEKLDLAAV KRDLHALMTT SQDWWPADFG HYGGLFIRMA WHSAGTYRTA
110 120 130 140 150
DGRGGAGEGQ QRFAPLNSWP DNANLDKARR LLWPIKQKYG RSISWADLLI
160 170 180 190 200
LTGNVALESM GFKTFGFAGG RADTWEPEDV YWGSEKIWLE LSGGPNSRYS
210 220 230 240 250
GDRQLENPLA AVQMGLIYVN PEGPDGNPDP VAAARDIRDT FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGPA SNVGPEPEAA GLEEQGLGWK SAYGTGKGAD
310 320 330 340 350
AITSGLEVTW TKTPTQWSNN FFENLFGYEW ELTKSPAGAH QWVAKDADAV
360 370 380 390 400
IPDAFDPSKK HRPTMLTTDL SLRFDPAYEK ISRRFHEHPD EFADAFARAW
410 420 430 440 450
FKLTHRDMGP RARYLGPEVP AEELLWQDPI PAVDHPLIDA ADVAALKAQV
460 470 480 490 500
LASGLSVSQL VSTAWAAAST FRGSDKRGGA NGARIRLAPQ KDWEANQPEQ
510 520 530 540 550
LATVLATLEA IRRTFNGAQS GGKRVSLADL IVLAGCAGVE QAAKNAGHAV
560 570 580 590 600
TVPFAPGRMD ASQEQTDVES MAVLEPLADG FRNYLKGKYR VPAEVLLVDK
610 620 630 640 650
AQLLTLSAPE MTVLLGGLRV LGANAGQSRH GVFTARAQAL TNDFFVNLLD
660 670 680 690 700
MSTEWKPASA DADVFEGRDR ATGALKWTGT RVDLVFGSHS QLRALAEVYA
710 720
SADAQEKFVR DFVAVWNKVM NLDRFDLA
Length:728
Mass (Da):79,535
Last modified:January 24, 2006 - v1
Checksum:i6FCD3E5A30ACFB1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC36439.1.
RefSeqiWP_009889205.1. NZ_CM000438.1.

Genome annotation databases

EnsemblBacteriaiABC36439; ABC36439; BTH_I1282.
KEGGibte:BTH_I1282.
PATRICi19305472. VBIBurTha36512_4045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC36439.1.
RefSeqiWP_009889205.1. NZ_CM000438.1.

3D structure databases

ProteinModelPortaliQ2SZ20.
SMRiQ2SZ20. Positions 14-728.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3663. BthCP01_E264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC36439; ABC36439; BTH_I1282.
KEGGibte:BTH_I1282.
PATRICi19305472. VBIBurTha36512_4045.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-1282-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_BURTA
AccessioniPrimary (citable) accession number: Q2SZ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.