ID   HEMH_BURTA              Reviewed;         355 AA.
AC   Q2SYZ9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Ferrochelatase;
DE            EC=4.99.1.1;
DE   AltName: Full=Protoheme ferro-lyase;
DE   AltName: Full=Heme synthetase;
GN   Name=hemH; OrderedLocusNames=BTH_I1303;
OS   Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 /
OS   CIP 106301).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R.,
RA   Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D.,
RA   Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA   Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D.,
RA   Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P.,
RA   Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F.,
RA   Roberts K., Hatch B., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC   -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC   -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC       from protoporphyrin-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR   EMBL; CP000086; ABC36533.1; -; Genomic_DNA.
DR   RefSeq; YP_441850.1; -.
DR   GeneID; 3847181; -.
DR   GenomeReviews; CP000086_GR; BTH_I1303.
DR   KEGG; bte:BTH_I1303; -.
DR   TIGR; BTH_I1303; -.
DR   HOGENOM; Q2SYZ9; -.
DR   OMA; Q2SYZ9; TIEEIGM.
DR   BioCyc; BTHA271848:BTH_I1303-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00323; -; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   PANTHER; PTHR11108; Ferrochelatase; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   ProDom; PD002792; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase;
KW   Metal-binding; Porphyrin biosynthesis.
FT   CHAIN         1    355       Ferrochelatase.
FT                                /FTId=PRO_1000059476.
FT   METAL       214    214       Iron (By similarity).
FT   METAL       295    295       Iron (By similarity).
SQ   SEQUENCE   355 AA;  39370 MW;  B04F91B3988547DF CRC64;
     MRFDLEPPSH ASAAHRVAVL LVNLGTPDEP TPRAVRRYLA QFLSDPRVVE IPQLVWQVIL
     RTLILPLRGR ASAKKYAAVW LPEGSPLRVY TERQVESLKP LFAANGYRVI VDYAMRYGTP
     SIADVLAQLK RAGAERVLLL PMYPQYSAST TATAFDAAFA ALGRMRNQPE VRTVRHYADH
     PAYIHALAEQ VRQYWAAHGR PAFDSGDKLV LSFHGVPKRT LDLGDPYHDQ CQQTAALLMS
     ALGLTTFECR VTFQSRFGKA EWLQPYTAPT LKELGAAGVR RADVFCPGFT ADCLETIEEI
     GMEVRDEFLH GGGKEFHRIP CLNASHAWIA ALGEIAAENL QGWPVRVATA PEAVT
//