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Q2SYI5

- APAH_BURTA

UniProt

Q2SYI5 - APAH_BURTA

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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene
apaH, BTH_I1468
Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-1468-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:BTH_I1468
OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000001930: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotationPRO_1000012052Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi271848.BTH_I1468.

Structurei

3D structure databases

ProteinModelPortaliQ2SYI5.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SYI5-1 [UniParc]FASTAAdd to Basket

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MTNFSSSPPI AFGDLQGCHA AYRQLFAQLS PAADTPLWFA GDLVNRGPAS    50
LATLREIVGL GERAVAVLGN HDLHLLAVAA GIRTLKPGDT IGEILDAPDA 100
DDLIEWVRHR PFAHFERGML MVHAGLLPQW DAALALELAD ELQRALRAPN 150
WRDTLRGLYG NDPNCWSPDL KKADRLRVAF NAFTRIRFCT PEGAMEFRAN 200
GGPASAPAGY LPWFDAPSRK TADVTVVFGH WAALGLMLRE NLVALDSGCV 250
WGNRLSAVRL ADDPAAREVA QVACERCGAA EE 282
Length:282
Mass (Da):30,602
Last modified:January 24, 2006 - v1
Checksum:iEDFBF07B49C68E59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000086 Genomic DNA. Translation: ABC36488.1.
RefSeqiYP_442014.1. NC_007651.1.

Genome annotation databases

EnsemblBacteriaiABC36488; ABC36488; BTH_I1468.
GeneIDi3847136.
KEGGibte:BTH_I1468.
PATRICi19305882. VBIBurTha36512_4249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000086 Genomic DNA. Translation: ABC36488.1 .
RefSeqi YP_442014.1. NC_007651.1.

3D structure databases

ProteinModelPortali Q2SYI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 271848.BTH_I1468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC36488 ; ABC36488 ; BTH_I1468 .
GeneIDi 3847136.
KEGGi bte:BTH_I1468.
PATRICi 19305882. VBIBurTha36512_4249.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251871.
KOi K01525.
OMAi INAFTRM.
OrthoDBi EOG66B3WP.

Enzyme and pathway databases

BioCyci BTHA271848:GJMY-1468-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
HAMAPi MF_00199. ApaH.
InterProi IPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
TIGRFAMsi TIGR00668. apaH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
    Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
    BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Entry informationi

Entry nameiAPAH_BURTA
AccessioniPrimary (citable) accession number: Q2SYI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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