ID   GLK_BURTA               Reviewed;         641 AA.
AC   Q2SYA5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Bifunctional protein glk;
DE   Includes:
DE     RecName: Full=Glucokinase;
DE              EC=2.7.1.2;
DE     AltName: Full=Glucose kinase;
DE   Includes:
DE     RecName: Full=Putative HTH-type transcriptional regulator;
GN   Name=glk; OrderedLocusNames=BTH_I1550;
OS   Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 /
OS   CIP 106301).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R.,
RA   Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D.,
RA   Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA   Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D.,
RA   Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P.,
RA   Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F.,
RA   Roberts K., Hatch B., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + D-glucose = ADP + D-glucose 6-phosphate.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the bacterial
CC       glucokinase family.
CC   -!- SIMILARITY: Contains 1 HTH rpiR-type DNA-binding domain.
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DR   EMBL; CP000086; ABC37839.1; -; Genomic_DNA.
DR   RefSeq; YP_442094.1; -.
DR   GeneID; 3850093; -.
DR   GenomeReviews; CP000086_GR; BTH_I1550.
DR   KEGG; bte:BTH_I1550; -.
DR   TIGR; BTH_I1550; -.
DR   HOGENOM; Q2SYA5; -.
DR   OMA; Q2SYA5; HYLQNIP.
DR   BioCyc; BTHA271848:BTH_I1550-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004340; F:glucokinase activity; IEA:HAMAP.
DR   GO; GO:0005529; F:sugar binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   HAMAP; MF_00524; fused; 1.
DR   InterPro; IPR003836; Glucokinase.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR000281; HTH_RpiR.
DR   InterPro; IPR001347; SIS.
DR   Pfam; PF02685; Glucokinase; 1.
DR   Pfam; PF01418; HTH_6; 1.
DR   Pfam; PF01380; SIS; 1.
DR   TIGRFAMs; TIGR00749; glk; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS51071; HTH_RPIR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA-binding; Glycolysis; Kinase;
KW   Membrane; Multifunctional enzyme; Nucleotide-binding; Transcription;
KW   Transcription regulation; Transferase; Transmembrane.
FT   CHAIN         1    641       Bifunctional protein glk.
FT                                /FTId=PRO_0000268801.
FT   TRANSMEM    576    596       Potential.
FT   DOMAIN      341    417       HTH rpiR-type.
FT   NP_BIND      23     28       ATP (Potential).
FT   DNA_BIND    377    396       H-T-H motif (By similarity).
FT   REGION        1    340       Glucokinase.
FT   REGION      341    641       Putative HTH-type transcriptional
FT                                regulator.
SQ   SEQUENCE   641 AA;  68475 MW;  06726A47707F8B7F CRC64;
     MSTGAQTKAA EASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA EYPTLTDAIR
     RYLKDVKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA TRRALGFDTL LVVNDFTALA
     MALPGLTDAQ RVQIGAGARR QNSVIGLMGP GTGLGVSGLI PADDRWIALG SEGGHATFAP
     MDEREDLVLQ YARRKYPHVS FERVCAGPGM EIIYRALAAR DKKRIAANVV TADIVERAHA
     GDALALEAVE CFCGILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG
     RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM RDALTPAERR
     VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC QGLSDFKLKL ATGLTGTIPM
     SHSQVHLGDT ATDFGAKVLD NTVSAILQLR EHLNFEHVEQ AIDILNNARR IEFYGLGNSN
     IVAQDAHYKF FRFGIPTIAY GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ
     AGAKVIAITS SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAS
     PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK E
//