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Q2SYA5 (GLK_BURTA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein glk

Including the following 2 domains:

  1. Glucokinase
    EC=2.7.1.2
    Alternative name(s):
    Glucose kinase
  2. Putative HTH-type transcriptional regulator
Gene names
Name:glk
Ordered Locus Names:BTH_I1550
OrganismBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]
Taxonomic identifier271848 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length641 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524

Subcellular location

Membrane; Single-pass membrane protein Potential HAMAP-Rule MF_00524.

Sequence similarities

In the N-terminal section; belongs to the bacterial glucokinase family.

Contains 1 HTH rpiR-type DNA-binding domain.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 641641Bifunctional protein glk HAMAP-Rule MF_00524
PRO_0000268801

Regions

Transmembrane576 – 59621Helical; Potential
Domain341 – 41777HTH rpiR-type
Domain461 – 600140SIS
Nucleotide binding23 – 286ATP Potential
DNA binding377 – 39620H-T-H motif By similarity
Region1 – 340340Glucokinase HAMAP-Rule MF_00524
Region341 – 641301Putative HTH-type transcriptional regulator HAMAP-Rule MF_00524

Sequences

Sequence LengthMass (Da)Tools
Q2SYA5 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 06726A47707F8B7F

FASTA64168,475
        10         20         30         40         50         60 
MSTGAQTKAA EASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA EYPTLTDAIR 

        70         80         90        100        110        120 
RYLKDVKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA TRRALGFDTL LVVNDFTALA 

       130        140        150        160        170        180 
MALPGLTDAQ RVQIGAGARR QNSVIGLMGP GTGLGVSGLI PADDRWIALG SEGGHATFAP 

       190        200        210        220        230        240 
MDEREDLVLQ YARRKYPHVS FERVCAGPGM EIIYRALAAR DKKRIAANVV TADIVERAHA 

       250        260        270        280        290        300 
GDALALEAVE CFCGILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG 

       310        320        330        340        350        360 
RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM RDALTPAERR 

       370        380        390        400        410        420 
VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC QGLSDFKLKL ATGLTGTIPM 

       430        440        450        460        470        480 
SHSQVHLGDT ATDFGAKVLD NTVSAILQLR EHLNFEHVEQ AIDILNNARR IEFYGLGNSN 

       490        500        510        520        530        540 
IVAQDAHYKF FRFGIPTIAY GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ 

       550        560        570        580        590        600 
AGAKVIAITS SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAS 

       610        620        630        640 
PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK E 

« Hide

References

[1]"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000086 Genomic DNA. Translation: ABC37839.1.
RefSeqYP_442094.1. NC_007651.1.

3D structure databases

ProteinModelPortalQ2SYA5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING271848.BTH_I1550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC37839; ABC37839; BTH_I1550.
GeneID3850093.
KEGGbte:BTH_I1550.
PATRIC19306054. VBIBurTha36512_4334.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1737.
HOGENOMHOG000257466.
KOK00845.
OMAQYARKKW.
OrthoDBEOG64BQ47.

Enzyme and pathway databases

BioCycBTHA271848:GJMY-1550-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00524. Glucokinase.
InterProIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
TIGRFAMsTIGR00749. glk. 1 hit.
PROSITEPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLK_BURTA
AccessionPrimary (citable) accession number: Q2SYA5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families