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Q2SYA5

- GLK_BURTA

UniProt

Q2SYA5 - GLK_BURTA

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Protein

Bifunctional protein glk

Gene
glk, BTH_I1550
Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 286ATP Reviewed prediction
DNA bindingi377 – 39620H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbohydrate binding Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. glucokinase activity Source: UniProtKB-EC
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-1550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:BTH_I1550
OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000001930: Chromosome I

Subcellular locationi

Membrane; Single-pass membrane protein Reviewed prediction UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei576 – 59621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Bifunctional protein glkUniRule annotationPRO_0000268801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi271848.BTH_I1550.

Structurei

3D structure databases

ProteinModelPortaliQ2SYA5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 41777HTH rpiR-typeAdd
BLAST
Domaini461 – 600140SISAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 340340GlucokinaseUniRule annotationAdd
BLAST
Regioni341 – 641301Putative HTH-type transcriptional regulatorUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.
Contains 1 SIS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SYA5-1 [UniParc]FASTAAdd to Basket

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MSTGAQTKAA EASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA    50
EYPTLTDAIR RYLKDVKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA 100
TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQIGAGARR QNSVIGLMGP 150
GTGLGVSGLI PADDRWIALG SEGGHATFAP MDEREDLVLQ YARRKYPHVS 200
FERVCAGPGM EIIYRALAAR DKKRIAANVV TADIVERAHA GDALALEAVE 250
CFCGILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG 300
RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM 350
RDALTPAERR VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC 400
QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR 450
EHLNFEHVEQ AIDILNNARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY 500
GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS 550
SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAS 600
PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK E 641
Length:641
Mass (Da):68,475
Last modified:January 24, 2006 - v1
Checksum:i06726A47707F8B7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000086 Genomic DNA. Translation: ABC37839.1.
RefSeqiYP_442094.1. NC_007651.1.

Genome annotation databases

EnsemblBacteriaiABC37839; ABC37839; BTH_I1550.
GeneIDi3850093.
KEGGibte:BTH_I1550.
PATRICi19306054. VBIBurTha36512_4334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000086 Genomic DNA. Translation: ABC37839.1 .
RefSeqi YP_442094.1. NC_007651.1.

3D structure databases

ProteinModelPortali Q2SYA5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 271848.BTH_I1550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC37839 ; ABC37839 ; BTH_I1550 .
GeneIDi 3850093.
KEGGi bte:BTH_I1550.
PATRICi 19306054. VBIBurTha36512_4334.

Phylogenomic databases

eggNOGi COG1737.
HOGENOMi HOG000257466.
KOi K00845.
OMAi QYARKKW.
OrthoDBi EOG64BQ47.

Enzyme and pathway databases

BioCyci BTHA271848:GJMY-1550-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
TIGRFAMsi TIGR00749. glk. 1 hit.
PROSITEi PS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
    Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
    BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Entry informationi

Entry nameiGLK_BURTA
AccessioniPrimary (citable) accession number: Q2SYA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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