Reviewed, UniProtKB/Swiss-Prot Q2SY72 (KGUA_BURTA)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BTH_I1586

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Guanylate kinase HAMAP MF_00328		PRO_0000266298
Regions
	Domain	21 – 199	179	Guanylate kinase-like
	Nucleotide binding	28 – 35	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SY72-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 71A54121CA0006AC	FASTA	227	25,185
	10 20 30 40 50 60 MTDSNRGGAA AHSLHAGVYP GNLFMVVAPS GAGKSTLVNA LLSKDPEICL SISYTTRKPR 70 80 90 100 110 120 SGEQDGQHYH FTTVEDFRAR HASHEFLESA EVHGNYYGTS RVWIEEQMKS GHDVLLEIDW 130 140 150 160 170 180 QGAQQVKKQF RNAVGIFILP PSLAALEERL KKRGQDEPNV ITRRLLAAGS EIAHAAEAEY 190 200 210 220 VVINETFEHA LAELECIVAA TRLRFTSQYA RHAELFVELG IHLPHAE

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000086 Genomic DNA. Translation: ABC37073.1.
RefSeq	YP_442127.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SY72.
Genome annotation databases
GeneID	3846845.
GenomeReviews	Gene locus BTH_I1586 in contig CP000086_GR.
KEGG	bte:BTH_I1586.
TIGR	BTH_I1586.
Phylogenomic databases
HOGENOM	Q2SY72.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I1586-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BURTA

Accession

Primary (citable) accession number: Q2SY72

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 24, 2006
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)