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Reviewed, UniProtKB/Swiss-Prot Q2SY18 (HLDD_BURTA)

Last modified June 16, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADP-L-glycero-D-manno-heptose-6-epimerase
    EC=5.1.3.20
Alternative name(s):
    ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      Short name=ADP-glyceromanno-heptose 6-epimerase
      Short name=ADP-hep 6-epimerase
      Short name=AGME
Gene names
Name: hldD
Ordered Locus Names: BTH_I1644
OrganismBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]
Taxonomic identifier271848 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

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Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity.

Catalytic activity

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601

Cofactor

Binds 1 NADP+ per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601

Subunit structure

Homopentamer By similarity.

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity.

Sequence similarities

Belongs to the sugar epimerase family. HldD subfamily.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandNADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: HAMAP

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionADP-glyceromanno-heptose 6-epimerase activity

Inferred from electronic annotation. Source: HAMAP

NADP or NADPH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601
PRO_0000255724

Regions

Nucleotide binding11 – 122NADP By similarity
Nucleotide binding32 – 332NADP By similarity
Nucleotide binding75 – 795NADP By similarity
Region200 – 2034Substrate binding By similarity

Sites

Active site1391Proton acceptor By similarity
Active site1771Proton acceptor By similarity
Binding site391NADP By similarity
Binding site541NADP By similarity
Binding site921NADP By similarity
Binding site1431NADP By similarity
Binding site1681Substrate By similarity
Binding site1691NADP; via amide nitrogen By similarity
Binding site1771NADP By similarity
Binding site1791Substrate; via carbonyl oxygen By similarity
Binding site1861Substrate By similarity
Binding site2131Substrate By similarity
Binding site2921Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2SY18-1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 143D7B34D082C794

FASTA33036,966
        10         20         30         40         50         60 
MTLIVTGAAG FIGANLVKAL NERGETRIIA VDNLTRADKF KNLVDCEIDD YLDKTEFVER 

        70         80         90        100        110        120 
FARGDFGKVR AVFHEGACSD TMETDGRYMM DNNFRYSRAV LDACLAQGAQ FLYASSAAIY 

       130        140        150        160        170        180 
GGSSRFVEER EVEAPLNVYG YSKFLFDQVI RRVMPGAKSQ IAGFRYFNVY GPRESHKGRM 

       190        200        210        220        230        240 
ASVAFHNFNQ FRAEGKVKLF GEYSGYGPGE QTRDFVSVED VAKVNLYFFD HPEKSGIFNL 

       250        260        270        280        290        300 
GTGRAQPFND IAATVVNTLR ALEGQPALTL AEQVEQGLVE YVPFPDALRG KYQCFTQADQ 

       310        320        330 
TKLRAAGYDA PFLTVQEGVD RYVRWLFGQL

« Hide

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Cross-references

Sequence databases

CP000086 Genomic DNA. Translation: ABC38509.1.
RefSeqYP_442181.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3849983.
GenomeReviewsGene locus BTH_I1644 in contig CP000086_GR.
KEGGbte:BTH_I1644.
TIGRBTH_I1644.

Phylogenomic databases

HOGENOMQ2SY18.
OMAQ2SY18. FGPNEYH.

Enzyme and pathway databases

BioCycBTHA271848:BTH_I1644-MON.

Family and domain databases

HAMAPMF_01601.
[Tree]
InterProIPR001509. Epimerase_deHydtase.
IPR011912. Heptose_epim.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10366:SF29. Heptose_epim. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02197. heptose_epim. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHLDD_BURTA
AccessionPrimary (citable) accession number: Q2SY18
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 24, 2006
Last modified: June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents