Reviewed, UniProtKB/Swiss-Prot Q2SXQ4 (PDXY_BURTA)

Names and origin

Protein names

Recommended name:
    Pyridoxamine kinase
      Short name=PM kinase
    EC=2.7.1.35

Gene names

Name:	pdxY
Ordered Locus Names:	BTH_I1763

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine By similarity.
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01639
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP pyridoxine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP pyridoxal kinase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Pyridoxamine kinase HAMAP MF_01639		PRO_0000269801
Regions
	Nucleotide binding	180 – 181	2	ATP By similarity
Sites
	Binding site	9	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SXQ4-1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 913217DE3998462E	FASTA	287	31,218
	10 20 30 40 50 60 MKNVLSIQSH VIYGHAGNSA AVFPMQRLGV NVWPLNTVQL SNHMQYGHWA GSAIDAAKME 70 80 90 100 110 120 QLVDGIAAIG ALKRCDAVLS GFLGSPAQAR AAVEIVRTVK ATNPNAWYFC DPAMGQTGGI 130 140 150 160 170 180 RPEPGVEEFI VAELPELADG MAPNHGELQK LAGQRIETVA EAVEACRSII RRGPRLILVK 190 200 210 220 230 240 HLHDRNSPAD RFNMLVVTET EAWIGQRPLY AFPRHPVGVG DLTSAIFVAR RLRGDSVRAA 250 260 270 280 FEHTLAAVHA VVKATYDARR YELELVAAQD EIAQPSEWFG AWVTGAD

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000086 Genomic DNA. Translation: ABC37853.1. Different initiation.
RefSeq	YP_442295.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3850009.
GenomeReviews	Gene locus BTH_I1763 in contig CP000086_GR.
KEGG	bte:BTH_I1763.
TIGR	BTH_I1763.
Phylogenomic databases
HOGENOM	Q2SXQ4.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I1763-MON.
Family and domain databases
HAMAP	MF_01639. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. [Graphical view]
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXY_BURTA

Accession

Primary (citable) accession number: Q2SXQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 21 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)