Q2SXC7 (PYRG_BURTA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 44.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: CTP synthase EC=6.3.4.2 Alternative name(s): CTP synthetase UTP--ammonia ligase | ||||
| Gene names |
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| Organism | Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 271848 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group |
Protein attributes
| Sequence length | 553 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP MF_01227 |
| Catalytic activity | ATP + UTP + NH3 = ADP + phosphate + CTP. HAMAP MF_01227 |
| Enzyme regulation | Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP MF_01227 |
| Pathway | Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP MF_01227 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01227 |
| Sequence similarities | Belongs to the CTP synthase family. Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CTP synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 553 | 553 | CTP synthase HAMAP MF_01227 | PRO_0000266086 | |||||
Regions | |||||||||
| Domain | 295 – 547 | 253 | Glutamine amidotransferase type-1 | ||||||
| Region | 1 – 257 | 257 | Aminator domain HAMAP MF_01227 | ||||||
Sites | |||||||||
| Active site | 383 | 1 | Nucleophile By similarity | ||||||
| Active site | 520 | 1 | By similarity | ||||||
| Active site | 522 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000086 Genomic DNA. Translation: ABC37894.1. |
| RefSeq | YP_442422.1. NC_007651.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2C5M based on UniProtKB P17812. |
| ProteinModelPortal | Q2SXC7. |
| SMR | Q2SXC7. Positions 2-549. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2SXC7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3848784. |
| GenomeReviews | Gene locus BTH_I1892 in contig CP000086_GR. |
| KEGG | bte:BTH_I1892. |
| PATRIC | 19306810. VBIBurTha36512_4700. |
| TIGR | BTH_I1892. |
Phylogenomic databases | |
| eggNOG | COG0504. |
| HOGENOM | HBG597806. |
| OMA | RVTMQKL. |
| ProtClustDB | PRK05380. |
Enzyme and pathway databases | |
| BioCyc | BTHA271848:BTH_I1892-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01227. PyrG. [Tree] |
| InterPro | IPR004468. CTP_synthase. IPR017456. CTP_synthase_N. IPR017926. GATASE_1. [Graphical view] |
| KO | K01937. |
| PANTHER | PTHR11550. PyrG_synth. 1 hit. |
| Pfam | PF06418. CTP_synth_N. 1 hit. PF00117. GATase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00337. PyrG. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRG_BURTA | ||||||||
| Accession | Primary (citable) accession number: Q2SXC7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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