Q2SWY8 (LPXD_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	BTH_I2037

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264353
Sites
	Active site	253	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SWY8 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: DD0D55513E661FD1	FASTA	361	36,953
	10 20 30 40 50 60 MALTLEALVA RFGGEIVGDG RREVGGLAPL DQAGPQHLAF LANPKYLAQV ETTAAGAVLI 70 80 90 100 110 120 APRDLEKLGA AANGRNFIIT PNPYAYFARV AQMFIDLAAP QRAAGVHPSA TIDPAAQVAA 130 140 150 160 170 180 SAVIGPHVSV EAGAVIGERV QLDANVFVGR GTRIGDDSHL YPNVTIYHGC TLGPRAIVHS 190 200 210 220 230 240 GAVIGSDGFG FAPDFVGEGD ARTGAWVKIP QVGGVKVGPD VEIGANTTID RGAMADTVID 250 260 270 280 290 300 ECVKIDNLVQ IGHNCRIGAY TVIAGCAGIA GSTTIGKHCM IGGAVGVAGH VTLGDYVIVT 310 320 330 340 350 360 AKSGVSKSLP KAGIYTSAFP AVEHGDWNKS AALVRNLDKL RDRIKALETA LAAREGDAGG A

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC36384.1.
RefSeq	YP_442561.1. NC_007651.1.
3D structure databases
ProteinModelPortal	Q2SWY8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SWY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3847031.
GenomeReviews	Gene locus BTH_I2037 in contig CP000086_GR.
KEGG	bte:BTH_I2037.
PATRIC	19307116. VBIBurTha36512_4847.
TIGR	BTH_I2037.
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	CFVGKNT.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I2037-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 5 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_BURTA

Accession

Primary (citable) accession number: Q2SWY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program