SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2SWY7

- FABZ_BURTA

UniProt

Q2SWY7 - FABZ_BURTA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene
fabZ, BTH_I2038
Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591 By similarity

GO - Molecular functioni

  1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-2039-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC:4.2.1.59)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name:
(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase
Gene namesi
Name:fabZ
Ordered Locus Names:BTH_I2038
OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000001930: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1601603-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotationPRO_0000242887Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi271848.BTH_I2038.

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 217
Beta strandi33 – 386
Turni39 – 413
Beta strandi42 – 487
Helixi54 – 574
Helixi68 – 8417
Beta strandi97 – 10711
Beta strandi116 – 12712
Beta strandi130 – 13910
Beta strandi142 – 15312

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H4GX-ray2.65A/B/C/D/E/F/G/H/I1-160[»]
ProteinModelPortaliQ2SWY7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0764.
HOGENOMiHOG000277829.
KOiK02372.
OMAiEPGDQLH.
OrthoDBiEOG6JTCGM.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SWY7-1 [UniParc]FASTAAdd to Basket

« Hide

MRRTIMSTEK INFDIHKILT LLPHRYPILL VDRVLELEPH KSIKALKNVT    50
VNEPFFTGHF PKRPVMPGVL IIEALAQAAA LLTFAEAEPK DPENTLYYFV 100
GIDNARFKRV VEPGDQLILN VTFERYIRGI WKFKAVAEVD GKVAAEAELM 150
CTVKTADAAP 160
Length:160
Mass (Da):18,087
Last modified:January 24, 2006 - v1
Checksum:i5A03FC5D9F004913
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000086 Genomic DNA. Translation: ABC39413.1.
RefSeqiWP_011402240.1. NC_007651.1.
YP_442562.1. NC_007651.1.

Genome annotation databases

EnsemblBacteriaiABC39413; ABC39413; BTH_I2038.
GeneIDi3848748.
KEGGibte:BTH_I2038.
PATRICi19307118. VBIBurTha36512_4848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000086 Genomic DNA. Translation: ABC39413.1 .
RefSeqi WP_011402240.1. NC_007651.1.
YP_442562.1. NC_007651.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4H4G X-ray 2.65 A/B/C/D/E/F/G/H/I 1-160 [» ]
ProteinModelPortali Q2SWY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 271848.BTH_I2038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC39413 ; ABC39413 ; BTH_I2038 .
GeneIDi 3848748.
KEGGi bte:BTH_I2038.
PATRICi 19307118. VBIBurTha36512_4848.

Phylogenomic databases

eggNOGi COG0764.
HOGENOMi HOG000277829.
KOi K02372.
OMAi EPGDQLH.
OrthoDBi EOG6JTCGM.

Enzyme and pathway databases

BioCyci BTHA271848:GJMY-2039-MONOMER.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
HAMAPi MF_00406. FabZ.
InterProi IPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view ]
Pfami PF07977. FabA. 1 hit.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
TIGRFAMsi TIGR01750. fabZ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
    Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
    BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Entry informationi

Entry nameiFABZ_BURTA
AccessioniPrimary (citable) accession number: Q2SWY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi