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Q2SWY7

- FABZ_BURTA

UniProt

Q2SWY7 - FABZ_BURTA

Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

    Catalytic activityi

    A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591UniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBTHA271848:GJMY-2039-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
    Alternative name(s):
    (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
    Short name:
    (3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
    Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
    Gene namesi
    Name:fabZUniRule annotation
    Ordered Locus Names:BTH_I2038
    OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
    Taxonomic identifieri271848 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000001930: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1601603-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000242887Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi271848.BTH_I2038.

    Structurei

    Secondary structure

    1
    160
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi15 – 217
    Beta strandi33 – 386
    Turni39 – 413
    Beta strandi42 – 487
    Helixi54 – 574
    Helixi68 – 8417
    Beta strandi97 – 10711
    Beta strandi116 – 12712
    Beta strandi130 – 13910
    Beta strandi142 – 15312

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H4GX-ray2.65A/B/C/D/E/F/G/H/I1-160[»]
    ProteinModelPortaliQ2SWY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0764.
    HOGENOMiHOG000277829.
    KOiK02372.
    OMAiEPGDQLH.
    OrthoDBiEOG6JTCGM.

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    HAMAPiMF_00406. FabZ.
    InterProiIPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view]
    PfamiPF07977. FabA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.
    TIGRFAMsiTIGR01750. fabZ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2SWY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRTIMSTEK INFDIHKILT LLPHRYPILL VDRVLELEPH KSIKALKNVT    50
    VNEPFFTGHF PKRPVMPGVL IIEALAQAAA LLTFAEAEPK DPENTLYYFV 100
    GIDNARFKRV VEPGDQLILN VTFERYIRGI WKFKAVAEVD GKVAAEAELM 150
    CTVKTADAAP 160
    Length:160
    Mass (Da):18,087
    Last modified:January 24, 2006 - v1
    Checksum:i5A03FC5D9F004913
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000086 Genomic DNA. Translation: ABC39413.1.
    RefSeqiWP_011402240.1. NC_007651.1.
    YP_442562.1. NC_007651.1.

    Genome annotation databases

    EnsemblBacteriaiABC39413; ABC39413; BTH_I2038.
    GeneIDi3848748.
    KEGGibte:BTH_I2038.
    PATRICi19307118. VBIBurTha36512_4848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000086 Genomic DNA. Translation: ABC39413.1 .
    RefSeqi WP_011402240.1. NC_007651.1.
    YP_442562.1. NC_007651.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H4G X-ray 2.65 A/B/C/D/E/F/G/H/I 1-160 [» ]
    ProteinModelPortali Q2SWY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 271848.BTH_I2038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC39413 ; ABC39413 ; BTH_I2038 .
    GeneIDi 3848748.
    KEGGi bte:BTH_I2038.
    PATRICi 19307118. VBIBurTha36512_4848.

    Phylogenomic databases

    eggNOGi COG0764.
    HOGENOMi HOG000277829.
    KOi K02372.
    OMAi EPGDQLH.
    OrthoDBi EOG6JTCGM.

    Enzyme and pathway databases

    BioCyci BTHA271848:GJMY-2039-MONOMER.

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    HAMAPi MF_00406. FabZ.
    InterProi IPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view ]
    Pfami PF07977. FabA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    TIGRFAMsi TIGR01750. fabZ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
      Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
      BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

    Entry informationi

    Entry nameiFABZ_BURTA
    AccessioniPrimary (citable) accession number: Q2SWY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3