Q2SWY7 (FABZ_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
EC=4.2.1.59

Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase

Gene names

Name:	fabZ
Ordered Locus Names:	BTH_I2038

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia thailandensis

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity. HAMAP-Rule MF_00406
Catalytic activity	A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00406
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00406.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 160

160

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ HAMAP-Rule MF_00406

PRO_0000242887

Sites

Active site

59

1

By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

160

Helix Strand Turn

Details...

Helix

15 – 21

7

Beta strand

33 – 38

6

Turn

39 – 41

3

Beta strand

42 – 48

7

Helix

54 – 57

4

Helix

68 – 84

17

Beta strand

97 – 107

11

Beta strand

116 – 127

12

Beta strand

130 – 139

10

Beta strand

142 – 153

12

Sequences

	Sequence		Length	Mass (Da)
	Q2SWY7 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 5A03FC5D9F004913	FASTA	160	18,087
	10 20 30 40 50 60 MRRTIMSTEK INFDIHKILT LLPHRYPILL VDRVLELEPH KSIKALKNVT VNEPFFTGHF 70 80 90 100 110 120 PKRPVMPGVL IIEALAQAAA LLTFAEAEPK DPENTLYYFV GIDNARFKRV VEPGDQLILN 130 140 150 160 VTFERYIRGI WKFKAVAEVD GKVAAEAELM CTVKTADAAP

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000086 Genomic DNA. Translation: ABC39413.1.

RefSeq

YP_442562.1. NC_007651.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4H4G	X-ray	2.65	A/B/C/D/E/F/G/H/I	1-160	[»]

ProteinModelPortal

Q2SWY7.

ModBase

Search...

Protein-protein interaction databases

STRING

271848.BTH_I2038.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

ABC39413; ABC39413; BTH_I2038.

GeneID

3848748.

KEGG

bte:BTH_I2038.

PATRIC

19307118. VBIBurTha36512_4848.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG0764.

HOGENOM

HOG000277829.

KO

K02372.

OMA

KERRGVA.

ProtClustDB

PRK00006.

Enzyme and pathway databases

BioCyc

BTHA271848:GJMY-2039-MONOMER.

Family and domain databases

HAMAP

MF_00406. FabZ.

InterPro

IPR013114. FabA_FabZ.
IPR010084. FabZ.
[Graphical view]

Pfam

PF07977. FabA. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01750. fabZ. 1 hit.

ProtoNet

Search...

Entry information

Entry name

FABZ_BURTA

Accession

Primary (citable) accession number: Q2SWY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program