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Q2SWY5

- LPXB_BURTA

UniProt

Q2SWY5 - LPXB_BURTA

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBTHA271848:GJMY-2041-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:BTH_I2040
    OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
    Taxonomic identifieri271848 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000001930: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Lipid-A-disaccharide synthasePRO_0000255168Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi271848.BTH_I2040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2SWY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2SWY5-1 [UniParc]FASTAAdd to Basket

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    MAFQPTPLRV ALVAGEPSGD LLGASLLGGL HAQLPASSRY YGIGGPRMTA    50
    VDFDAHWPME KLAVRGYVEA LKHIPEILRI RGELKRQLLA EPPDAFIGID 100
    APDFNFGLEQ ALRGAGIPTV HFVCPSIWAW RGGRIKKIVK AVDHMLCLFP 150
    FEPELLEKAG VAATFVGHPL ADEIPLEPDM HGARIALGLP DSGPVIAVLP 200
    GSRRSEIELI GPTFFDAMAL MQQREPGVRF VVPAATPALR ELLQPLVDAH 250
    PLLSVTLTEG RAQVAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
    GQIMRRQGYL PYVGLPNILA GRFVVPELLQ HFATPEALAD ATLTQLRDDA 350
    NRRTLTGIFT DMHLALRQNT AQRAAEAVAR VIDSRKPH 388
    Length:388
    Mass (Da):42,128
    Last modified:January 24, 2006 - v1
    Checksum:iF0B56279745841C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000086 Genomic DNA. Translation: ABC37543.1.
    RefSeqiWP_009890460.1. NZ_CM000438.1.
    YP_442564.1. NC_007651.1.

    Genome annotation databases

    EnsemblBacteriaiABC37543; ABC37543; BTH_I2040.
    GeneIDi3848338.
    KEGGibte:BTH_I2040.
    PATRICi19307122. VBIBurTha36512_4850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000086 Genomic DNA. Translation: ABC37543.1 .
    RefSeqi WP_009890460.1. NZ_CM000438.1.
    YP_442564.1. NC_007651.1.

    3D structure databases

    ProteinModelPortali Q2SWY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 271848.BTH_I2040.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC37543 ; ABC37543 ; BTH_I2040 .
    GeneIDi 3848338.
    KEGGi bte:BTH_I2040.
    PATRICi 19307122. VBIBurTha36512_4850.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BTHA271848:GJMY-2041-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
      Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
      BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

    Entry informationi

    Entry nameiLPXB_BURTA
    AccessioniPrimary (citable) accession number: Q2SWY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3