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Q2SWP3 (Q2SWP3_BURTA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419
Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419
Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419
Gene names
Name:purL HAMAP-Rule MF_00419 EMBL ABC36297.1
Ordered Locus Names:BTH_I2135
OrganismBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP] EMBL ABC36297.1
Taxonomic identifier271848 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length1414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. SAAS SAAS010073 HAMAP-Rule MF_00419

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. SAAS SAAS010073 HAMAP-Rule MF_00419

Subunit structure

Monomer By similarity. SAAS SAAS010073 HAMAP-Rule MF_00419

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00419.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. SAAS SAAS010073 HAMAP-Rule MF_00419

In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding385 – 39612ATP By similarity HAMAP-Rule MF_00419

Sites

Active site12581Nucleophile By similarity HAMAP-Rule MF_00419
Active site13791 By similarity HAMAP-Rule MF_00419
Active site13811 By similarity HAMAP-Rule MF_00419

Sequences

Sequence LengthMass (Da)Tools
Q2SWP3 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: EA0C3893465E2B3F

FASTA1,414152,123
        10         20         30         40         50         60 
MIAPNEARRP IRCARRRRRA GVRGTRERPL GGRLPGIITA FLTPHVASLR DSSTSVQPMA 

        70         80         90        100        110        120 
HFSCFPGASA LSDFRQTRLL DALKQIDGDI VAVRGQYLHF VNAHEPLTAD DEARIGALMH 

       130        140        150        160        170        180 
YGAPFEPAAE KGATETFVVL PRFGTVSPWA SKATDIAQHC GLARVRRIER GIEFTVTLKA 

       190        200        210        220        230        240 
GILGVGAKKA LAADARAAVA AALHDRMTES VVASRDDARH LFDELPAKPL ATVDVLAHGR 

       250        260        270        280        290        300 
TALERANVEL GLALADDEID YLVDAFVKLE RNPTDVELMM FAQANSEHCR HKIFNAQWTI 

       310        320        330        340        350        360 
DGQAQDMSLF AMIRNTEKMS PQGTIVAYSD NSSIMMGAQA ERWFPRGANA GGEPGERYGR 

       370        380        390        400        410        420 
HTELTHTLMK VETHNHPTAI SPFPGAATGA GGEIRDEGAT GRGARPKAGL TGFTVSNLDL 

       430        440        450        460        470        480 
PGAREPWENA RDAAQPLAAR DANEPHAPYG RPDRIASPLS IMIDGPLGGA AFNNEFGRPN 

       490        500        510        520        530        540 
LGGYFRVYEQ NVGGQVRGYH KPIMIAGGIG NISDAHTHKH DVPAGSLLIQ IGGPGMRIGM 

       550        560        570        580        590        600 
GGGAASSMAT GANTAELDFD SVQRGNPEIE RRAQEVINGC WQLGEQNPIL SIHDVGAGGL 

       610        620        630        640        650        660 
SNAFPEIVDG AGKGARFELR KVALEESGLS PREIWSNEAQ ERYVLAIAPA DLPRFEAICA 

       670        680        690        700        710        720 
RERCPFSVVG VATDERRLQL VDDEAAGAAE YPVDMPMEVL LGKPPRMHRD VKRVAVERAG 

       730        740        750        760        770        780 
VDVTGLSLAD IARDVLKHPT VASKSFLITI GDRTVGGTSV RDQMVGPWQV PVADCAVTAL 

       790        800        810        820        830        840 
DYAGFAGEAM TMAERTPLAV IDAPASGRMA VGEAITNIAA APIASLDKLK LSANWMAACG 

       850        860        870        880        890        900 
TEGEDAKLFD TVKAIGMELC PALGIGIPVG KDSLSMKTKW DENGVAKEVV SPVSLIISAF 

       910        920        930        940        950        960 
APVEDVRRHL TPQLRRVADV GASVLIAIDL GRGKHRLGGS ILAQVTQQVG DDTPDVDDPE 

       970        980        990       1000       1010       1020 
DLKRFFAAIQ SLNARNLLLA YHDRSDGGLW ATVCEMAFAG HAGVSLNVDM LTLDPQHESD 

      1030       1040       1050       1060       1070       1080 
YGDAKDWAKQ TSGRREDRTI RALFSEELGA VVQVRAADRD AVLGALREQG LSACSHVIGA 

      1090       1100       1110       1120       1130       1140 
VNETDVIEVY RDAKKIYEAP RVELQRAWSE VSWRIARLRD NPACADAEYD ALLDAGDPGL 

      1150       1160       1170       1180       1190       1200 
APVLTFDPAE DIAAPFIATG ARPRVAILRE QGVNSHLETA YAFDRAGFDA HDVHMSDLLA 

      1210       1220       1230       1240       1250       1260 
GRATLADFAG AVACGGFSYG DVLGAGEGWA KTIRFNDKLA DMFAAFFARP DTFALGICNG 

      1270       1280       1290       1300       1310       1320 
CQMMSSLASM IPGADAWPKF TRNKSEQFEA RFSLVEVQGS PSIFFAGMEG SRIPVAVAHG 

      1330       1340       1350       1360       1370       1380 
EGYADFSQQG DQSRVAVAMR YVDHRGEATE RYPFNPNGSP AGITSVTTAD GRFTVLMPHM 

      1390       1400       1410 
ERVHRTVTMS WHPEGWGEAS PWLRVFRNAR RWIG

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References

[1]"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000086 Genomic DNA. Translation: ABC36297.1.
RefSeqYP_442656.1. NC_007651.1.

3D structure databases

ProteinModelPortalQ2SWP3.
ModBaseSearch...

Protein-protein interaction databases

STRING271848.BTH_I2135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC36297; ABC36297; BTH_I2135.
GeneID3846944.
KEGGbte:BTH_I2135.
PATRIC19307324. VBIBurTha36512_4948.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000261359.
KOK01952.
OMATVKAVGM.
ProtClustDBPRK05297.

Enzyme and pathway databases

BioCycBTHA271848:GJMY-2136-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR017926. GATASE_1.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2SWP3_BURTA
AccessionPrimary (citable) accession number: Q2SWP3
Entry history
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info