Q2SWN9 (MSRB_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	BTH_I2139

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000145362
Sites
	Active site	128	1	Nucleophile By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	58	1	Zinc By similarity
	Metal binding	104	1	Zinc By similarity
	Metal binding	107	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SWN9 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 478CC2E287E5C5CE	FASTA	143	16,321
	10 20 30 40 50 60 MSGDRDDKRY PYPKDDAELR RRLTPMQYEV TQHAATERPF TGEYTDTEDA GIYHCVVCGT 70 80 90 100 110 120 ALFESGAKYH SGCGWPSYFK PIDAEVIDEK MDYTHGMTRV EVRCNQCGAH LGHVFEDGPR 130 140 DKTGLRYCIN SAALNFEAKP EWK

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC39078.1.
RefSeq	YP_442660.1. NC_007651.1.
3D structure databases
ProteinModelPortal	Q2SWN9.
SMR	Q2SWN9. Positions 10-140.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SWN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3850048.
GenomeReviews	Gene locus BTH_I2139 in contig CP000086_GR.
KEGG	bte:BTH_I2139.
PATRIC	19307332. VBIBurTha36512_4952.
TIGR	BTH_I2139.
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	FTDGPVD.
ProtClustDB	CLSK930638.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I2139-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_BURTA

Accession

Primary (citable) accession number: Q2SWN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program