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Q2SW40 (XYLA_BURTA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylose isomerase
EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:BTH_I2338
OrganismBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]
Taxonomic identifier271848 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_00455

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00455

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Sequence caution

The sequence ABC39030.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Xylose isomerase HAMAP-Rule MF_00455
PRO_0000236960

Sites

Active site1001 By similarity
Active site1031 By similarity
Metal binding2311Magnesium 1 By similarity
Metal binding2671Magnesium 1 By similarity
Metal binding2671Magnesium 2 By similarity
Metal binding2701Magnesium 2 By similarity
Metal binding2951Magnesium 1 By similarity
Metal binding3061Magnesium 2 By similarity
Metal binding3081Magnesium 2 By similarity
Metal binding3381Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2SW40 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: B5D02E609DD74C54

FASTA44049,424
        10         20         30         40         50         60 
MSYFEHIPAI RYEGPQSDNP LAYRHYDRTK RVLGKTLEEH LRIAVCYWHT FVWPGQDVFG 

        70         80         90        100        110        120 
QGALRRPWQQ PGEPLERARQ KADAAFAFFT KLGTPFYTFH DTDVAPEGAN LHEYVENFAR 

       130        140        150        160        170        180 
MVDYLGEHQQ ASGVRLLWGT ANLFSHPRFA AGAATSPNPD AFAWAATQVC HALDATHRLG 

       190        200        210        220        230        240 
GENYVLWGGR EGYETLLNTD LAREREQLAR FLAMVVEHKH RIGFTGALLI EPKPQEPTKH 

       250        260        270        280        290        300 
QYDYDVATVH GLLTQYGLQN EIRVNIEANH ATLAGHSFHH EIANAFALGV FGSVDANRGD 

       310        320        330        340        350        360 
PQNGWDTDQF PNSVEELTLA FYEILRHGGF TTGGMNFDAK VRRQSVDPED LFHGHIGAID 

       370        380        390        400        410        420 
VLALALERAA VLVENDRLDA LRRRRYAQWD SEFGRKILAG GYSLQSLAAD ALARGVNPQH 

       430        440 
ASGAQERLEN IVNQAIYALR

« Hide

References

[1]"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000086 Genomic DNA. Translation: ABC39030.1. Different initiation.
RefSeqYP_442859.2. NC_007651.1.

3D structure databases

ProteinModelPortalQ2SW40.
SMRQ2SW40. Positions 2-438.
ModBaseSearch...

Protein-protein interaction databases

STRING271848.BTH_I2338.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC39030; ABC39030; BTH_I2338.
GeneID3848180.
KEGGbte:BTH_I2338.
PATRIC19307786. VBIBurTha36512_5179.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2115.
HOGENOMHOG000252293.
KOK01805.
ProtClustDBPRK05474.

Enzyme and pathway databases

BioCycBTHA271848:GJMY-2339-MONOMER.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_BURTA
AccessionPrimary (citable) accession number: Q2SW40
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 1, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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