Reviewed, UniProtKB/Swiss-Prot Q2SW40 (XYLA_BURTA)

Names and origin

Protein names

Recommended name:
    Xylose isomerase
    EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	BTH_I2338

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Xylose isomerase HAMAP MF_00455		PRO_0000236960
Sites
	Active site	100	1	By similarity
	Active site	103	1	By similarity
	Metal binding	231	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 2 By similarity
	Metal binding	270	1	Magnesium 2 By similarity
	Metal binding	295	1	Magnesium 1 By similarity
	Metal binding	306	1	Magnesium 2 By similarity
	Metal binding	308	1	Magnesium 2 By similarity
	Metal binding	338	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SW40-1 [UniParc]. Last modified May 30, 2006. Version 2. Checksum: B5D02E609DD74C54	FASTA	440	49,424
	10 20 30 40 50 60 MSYFEHIPAI RYEGPQSDNP LAYRHYDRTK RVLGKTLEEH LRIAVCYWHT FVWPGQDVFG 70 80 90 100 110 120 QGALRRPWQQ PGEPLERARQ KADAAFAFFT KLGTPFYTFH DTDVAPEGAN LHEYVENFAR 130 140 150 160 170 180 MVDYLGEHQQ ASGVRLLWGT ANLFSHPRFA AGAATSPNPD AFAWAATQVC HALDATHRLG 190 200 210 220 230 240 GENYVLWGGR EGYETLLNTD LAREREQLAR FLAMVVEHKH RIGFTGALLI EPKPQEPTKH 250 260 270 280 290 300 QYDYDVATVH GLLTQYGLQN EIRVNIEANH ATLAGHSFHH EIANAFALGV FGSVDANRGD 310 320 330 340 350 360 PQNGWDTDQF PNSVEELTLA FYEILRHGGF TTGGMNFDAK VRRQSVDPED LFHGHIGAID 370 380 390 400 410 420 VLALALERAA VLVENDRLDA LRRRRYAQWD SEFGRKILAG GYSLQSLAAD ALARGVNPQH 430 440 ASGAQERLEN IVNQAIYALR

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC39030.1. Different initiation.
RefSeq	YP_442859.2.
3D structure databases
SMR	Q2SW40. Positions 2-438.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SW40.
Genome annotation databases
GeneID	3848180.
GenomeReviews	Gene locus BTH_I2338 in contig CP000086_GR.
KEGG	bte:BTH_I2338.
TIGR	BTH_I2338.
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HBG297199.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I2338-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_BURTA

Accession

Primary (citable) accession number: Q2SW40

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)