Reviewed, UniProtKB/Swiss-Prot Q2SUY6 (UPPP2_BURTA)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	BTH_I2750

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000250229
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	44 – 64	21	Potential
	Transmembrane	87 – 107	21	Potential
	Transmembrane	114 – 134	21	Potential
	Transmembrane	150 – 170	21	Potential
	Transmembrane	190 – 210	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	251 – 271	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2SUY6-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 280F6D50F9DB3276	FASTA	276	30,265
	10 20 30 40 50 60 MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV ALHLGTAFAL 70 80 90 100 110 120 LWYFRERWIA LIAGFFASLN GRKNDEGHLM WALIIGTIPA GLVGLLLEKR IERVFHDLRI 130 140 150 160 170 180 VAVALIVNGI LLWLGDRIQR ARAHRPPEKL TFKQAFFVGL AQVGALIPGF SRSGLTMIAG 190 200 210 220 230 240 NAAGLTAEKA AEFSFLLGTP IIFAAGLLEL PKLFHAPDQL ADALLGGVLT AIAAYLSVRF 250 260 270 LMRYFEGRGR LASFGLYCAL AGLFCLGWFM FHAQPV

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000086 Genomic DNA. Translation: ABC36529.1.
RefSeq	YP_443263.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3847177.
GenomeReviews	Gene locus BTH_I2750 in contig CP000086_GR.
KEGG	bte:BTH_I2750.
TIGR	BTH_I2750.
Phylogenomic databases
HOGENOM	Q2SUY6.
OMA	Q2SUY6. FALLWYF.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP2_BURTA

Accession

Primary (citable) accession number: Q2SUY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)