ID   TRPC_BURTA              Reviewed;         261 AA.
AC   Q2SUI0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=BTH_I2912;
OS   Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 /
OS   CIP 106301).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R.,
RA   Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D.,
RA   Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA   Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D.,
RA   Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P.,
RA   Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F.,
RA   Roberts K., Hatch B., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC       phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the trpC family.
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DR   EMBL; CP000086; ABC37677.1; -; Genomic_DNA.
DR   RefSeq; YP_443419.1; -.
DR   GeneID; 3847584; -.
DR   GenomeReviews; CP000086_GR; BTH_I2912.
DR   KEGG; bte:BTH_I2912; -.
DR   TIGR; BTH_I2912; -.
DR   HOGENOM; Q2SUI0; -.
DR   OMA; Q2SUI0; PLLCKDF.
DR   BioCyc; BTHA271848:BTH_I2912-MON; -.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:HAMAP.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00134; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GPS_central.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   ProDom; PD001511; IGPS; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Lyase; Tryptophan biosynthesis.
FT   CHAIN         1    261       Indole-3-glycerol phosphate synthase.
FT                                /FTId=PRO_1000018463.
SQ   SEQUENCE   261 AA;  28281 MW;  83C867E79189BD61 CRC64;
     MSDILDKIIA VKREEIAAAL KSAPLEELKL QASARDSRDF VGALRGKHAA GHAAVIAEVK
     KASPSKGVLR ERFVPADIAR SYAEHGAACL SVLTDEQFFQ GSARYLEEAR AACNLPVLRK
     DFIVDPYQVL EARAMGADAI LLIAAALDTP LMVDLEAYAH SLGLAVLVEV HNRDELSAAL
     ELKTPLVGIN NRNLRTFETT IDTTLGMLDA IPDDRIVVTE SGILSRADVE RMEAAGVHTF
     LVGEAFMRAE NPGAELARMF F
//