Reviewed, UniProtKB/Swiss-Prot Q2SUA7 (HIS4_BURTA)

Names and origin

Protein names

Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
    EC=5.3.1.16
Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	BTH_I2988

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the hisA/hisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP MF_01014		PRO_0000290458
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	131	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SUA7-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: C40580F9C7E013FE	FASTA	251	26,588
	10 20 30 40 50 60 MLLIPAIDLK DGQCVRLKQG DMDQATIFSE DPAAMARKWV DLGARRLHLV DLNGAFAGKP 70 80 90 100 110 120 KNLEAIEAIL GEVGDEIPVQ LGGGIRSLET IEKYLDAGLS YVIIGTAAVK DPGFLRDACS 130 140 150 160 170 180 AFAGNIIVGL DAKDGKVATD GWSKLTGHEV IDLAQKFEDY GVESIVYTDI GRDGMLQGIN 190 200 210 220 230 240 IEATVKLAQA VGIPVIASGG LSNIVDIEKL CEVEDEGIEG VICGRAIYSG DLDFAAAQKR 250 ADELNGELDD A

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000086 Genomic DNA. Translation: ABC37752.1.
RefSeq	YP_443492.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3847621.
GenomeReviews	Gene locus BTH_I2988 in contig CP000086_GR.
KEGG	bte:BTH_I2988.
TIGR	BTH_I2988.
Phylogenomic databases
HOGENOM	Q2SUA7.
OMA	Q2SUA7. VATRGWL.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I2988-MON.
Family and domain databases
HAMAP	MF_01014. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006063. His4. IPR006062. His_biosynth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
TIGRFAMs	TIGR00007. His4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_BURTA

Accession

Primary (citable) accession number: Q2SUA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)