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Protein

Aquaporin Z

Gene

aqpZ

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei42 – 421Involved in tetramerization or stability of the tetramerUniRule annotation
Sitei65 – 651Selectivity filterUniRule annotation
Sitei196 – 1961Selectivity filterUniRule annotation
Sitei205 – 2051Selectivity filterUniRule annotation
Sitei211 – 2111Selectivity filterUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-3190-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin ZUniRule annotation
Gene namesi
Name:aqpZUniRule annotation
Ordered Locus Names:BTH_I3190Imported
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)Imported
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalUniRule annotationAdd
BLAST
Transmembranei56 – 7621HelicalUniRule annotationAdd
BLAST
Transmembranei104 – 12421HelicalUniRule annotationAdd
BLAST
Transmembranei153 – 17321HelicalUniRule annotationAdd
BLAST
Transmembranei182 – 20221HelicalUniRule annotationAdd
BLAST
Transmembranei228 – 24821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2STR5.
SMRiQ2STR5. Positions 25-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi85 – 873NPA 1UniRule annotation
Motifi208 – 2103NPA 2UniRule annotation

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).UniRule annotation

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiLVPNSMS.
OrthoDBiEOG6GFGN7.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2STR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPCFCGAIR YRFSRPGTTP MKLPQRLAAE VFGTFWLVLG GCGSAVLAAA
60 70 80 90 100
FPGLGIGFAG VALAFGLTVL TMAFAIGHVS GCHLNPAVSV GLTVAGRFPA
110 120 130 140 150
RDLVPYIVAQ VIGATLGAFV LYLIATGKPG FDVVGSGFAT NGYDARSPGH
160 170 180 190 200
YSLAAAFICE VVMTGFFLFV ILGSTDKRAP AGFAPIAIGL CLTLIHLISI
210 220 230 240 250
PVTNTSVNPA RSTGPALFVG GEAIGQLWLF WVAPIIGAAI AGVVYPLVAG

RDES
Length:254
Mass (Da):26,135
Last modified:January 24, 2006 - v1
Checksum:iCF1B469D914E8B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC39049.1.

Genome annotation databases

EnsemblBacteriaiABC39049; ABC39049; BTH_I3190.
KEGGibte:BTH_I3190.
PATRICi19309630. VBIBurTha36512_6077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC39049.1.

3D structure databases

ProteinModelPortaliQ2STR5.
SMRiQ2STR5. Positions 25-231.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC39049; ABC39049; BTH_I3190.
KEGGibte:BTH_I3190.
PATRICi19309630. VBIBurTha36512_6077.

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiLVPNSMS.
OrthoDBiEOG6GFGN7.

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-3190-MONOMER.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
    Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
    BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301Imported.

Entry informationi

Entry nameiQ2STR5_BURTA
AccessioniPrimary (citable) accession number: Q2STR5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.