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Protein

Aquaporin Z

Gene

aqpZ

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei42Involved in tetramerization or stability of the tetramerUniRule annotation1
Sitei65Selectivity filterUniRule annotation1
Sitei196Selectivity filterUniRule annotation1
Sitei205Selectivity filterUniRule annotation1
Sitei211Selectivity filterUniRule annotation1

GO - Molecular functioni

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin ZUniRule annotation
Gene namesi
Name:aqpZUniRule annotation
Ordered Locus Names:BTH_I3190Imported
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)Imported
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalUniRule annotationAdd BLAST21
Transmembranei57 – 82HelicalUniRule annotationAdd BLAST26
Transmembranei103 – 125HelicalUniRule annotationAdd BLAST23
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei223 – 248HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2STR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi85 – 87NPA 1UniRule annotation3
Motifi208 – 210NPA 2UniRule annotation3

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).UniRule annotation

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiELFGTFW.
OrthoDBiPOG091H021C.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2STR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPCFCGAIR YRFSRPGTTP MKLPQRLAAE VFGTFWLVLG GCGSAVLAAA
60 70 80 90 100
FPGLGIGFAG VALAFGLTVL TMAFAIGHVS GCHLNPAVSV GLTVAGRFPA
110 120 130 140 150
RDLVPYIVAQ VIGATLGAFV LYLIATGKPG FDVVGSGFAT NGYDARSPGH
160 170 180 190 200
YSLAAAFICE VVMTGFFLFV ILGSTDKRAP AGFAPIAIGL CLTLIHLISI
210 220 230 240 250
PVTNTSVNPA RSTGPALFVG GEAIGQLWLF WVAPIIGAAI AGVVYPLVAG

RDES
Length:254
Mass (Da):26,135
Last modified:January 24, 2006 - v1
Checksum:iCF1B469D914E8B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC39049.1.

Genome annotation databases

EnsemblBacteriaiABC39049; ABC39049; BTH_I3190.
KEGGibte:BTH_I3190.

Similar proteinsi

Entry informationi

Entry nameiQ2STR5_BURTA
AccessioniPrimary (citable) accession number: Q2STR5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported