Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2STK2 (GCSP_BURTA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BTH_I3253
OrganismBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]
Taxonomic identifier271848 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length975 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 975975Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045576

Amino acid modifications

Modified residue7231N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2STK2 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 36FA585C545A4BB3

FASTA975104,360
        10         20         30         40         50         60 
MKLEHPDRLM KRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFATR AALIDAVIPA 

        70         80         90        100        110        120 
SIRRAETLPL GPFAQPLSEA EALAALRELA DKNQVFRSYI GQGYYDTHTP AVILRNVLEN 

       130        140        150        160        170        180 
PAWYTAYTPY QPEISQGRLE ALLNFQQMVA DLTGLEISNA SLLDEATAAA EAMTLLQRVG 

       190        200        210        220        230        240 
KPQSNVFYVA DDVLPQTLEV IKTRAKPIGI EVKSGPAADA AAANAFGVLL QYPGVNGDVR 

       250        260        270        280        290        300 
DYRALADAIH AAGGHVVVAA DILALTVLTP PGEWGADVAV GNTQRFGVPM GFGGPHAAYM 

       310        320        330        340        350        360 
AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA QALLAIMASM 

       370        380        390        400        410        420 
YAVYHGPRGL KTIALRVNRI AALVAAGVKQ LGFATVNDTF FDTLTIDTGA RTAQIHALAN 

       430        440        450        460        470        480 
AKRINLRRVS DTRVGISVDE TTTRGDLAEL LGVFAQAAGG TAPDVDALDA GLADTAALPA 

       490        500        510        520        530        540 
GLQRTSAYLT HHVFNRHHSE TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV 

       550        560        570        580        590        600 
TWPEFGRIHP FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA 

       610        620        630        640        650        660 
YHESRGESHR NVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIDDL KAKAEQHAND 

       670        680        690        700        710        720 
LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM NAMVGLTAPG QFGGDVSHLN 

       730        740        750        760        770        780 
LHKTFCIPHG GGGPGVGPVA VGAHLAKFLP NQRSTGYARA EDGIGAVSAA PYGSASILPI 

       790        800        810        820        830        840 
SWMYIAMMGA KNLTAATETA ILNANYIAKR LAPHYPVLYS GPGGLVAHEC ILDLRPIKDS 

       850        860        870        880        890        900 
SGITVDDVAK RLMDYGFHAP TMSFPVPGTL MVEPTESESQ EELDRFVAAM IAIRDEIRAV 

       910        920        930        940        950        960 
EEGRADREDN PLRHAPHTAA VVTANEWPHA YSREQAAYPV ASLVANKYWP PVGRADNAYG 

       970 
DRNLFCSCVP VSDYA 

« Hide

References

[1]"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000086 Genomic DNA. Translation: ABC38436.1.
RefSeqYP_443747.1. NC_007651.1.

3D structure databases

ProteinModelPortalQ2STK2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING271848.BTH_I3253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC38436; ABC38436; BTH_I3253.
GeneID3848625.
KEGGbte:BTH_I3253.
PATRIC19309762. VBIBurTha36512_6143.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycBTHA271848:GJMY-3253-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BURTA
AccessionPrimary (citable) accession number: Q2STK2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families