Reviewed, UniProtKB/Swiss-Prot Q2STF3 (DCUP_BURTA)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	BTH_I3304

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023885
Regions
	Region	28 – 32	5	Substrate binding By similarity
Sites
	Binding site	78	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity
	Binding site	215	1	Substrate By similarity
	Binding site	333	1	Substrate By similarity
	Site	78	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2STF3-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 20BF248D8BFA8136	FASTA	364	39,497
	10 20 30 40 50 60 MAQTLINDTF LRALLREPTD YTPIWLMRQA GRYLPEYNAT RARAGSFLGL AKHPDYATEV 70 80 90 100 110 120 TLQPLERFPL DAAILFSDIL TIPDAMGLGL DFAAGEGPKF AHPVRTEADV AKLAVPDIGA 130 140 150 160 170 180 TLGYVTDAVR EIRRALTDGE GRQRVPLIGF SGSPWTLACY MVEGGGSDDF RTVKSMAYAR 190 200 210 220 230 240 PDLMHRILDV NAQAVAAYLN AQIEAGAQAV MIFDTWGGAL ADGAYQRFSL DYIRRVVAQL 250 260 270 280 290 300 KREHDGARVP AIAFTKGGGL WLEDLAATGV DAVGLDWTVN LGRARERVAG RVALQGNLDP 310 320 330 340 350 360 TILFAPPEAI RAEARAVLDS YGNHPGHVFN LGHGISQFTP PEHVAELVDE VHRHSRAIRS GTGS

References

[1]

Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000086 Genomic DNA. Translation: ABC37811.1.
RefSeq	YP_443796.1.
3D structure databases
SMR	Q2STF3. Positions 4-359.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2STF3.
Genome annotation databases
GeneID	3849034.
GenomeReviews	Gene locus BTH_I3304 in contig CP000086_GR.
KEGG	bte:BTH_I3304.
TIGR	BTH_I3304.
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HBG628392.
OMA	QIFDTWG.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_I3304-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BURTA

Accession

Primary (citable) accession number: Q2STF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)