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Q2SSX9

- KITH_MYCCT

UniProt

Q2SSX9 - KITH_MYCCT

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Protein
Thymidine kinase
Gene
tdk, MCAP_0143
Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptor Reviewed prediction
Metal bindingi160 – 1601Zinc By similarity
Metal bindingi163 – 1631Zinc By similarity
Metal bindingi198 – 1981Zinc By similarity
Metal bindingi201 – 2011Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 328ATP By similarity
Nucleotide bindingi103 – 1064ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMCAP340047:GC0H-142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:MCAP_0143
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001928: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Thymidine kinaseUniRule annotation
PRO_0000242795Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi340047.MCAP_0143.

Structurei

3D structure databases

ProteinModelPortaliQ2SSX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SSX9-1 [UniParc]FASTAAdd to Basket

« Hide

MTELDINEIE AYNSNKMGWI ELITGCMFAG KTEEFIRRLK VLSYAKKRVL    50
AFKPSIDNRY SVENIISHSG SKLDSYLVKS SDEIKQIVEK ENQIQQVDVI 100
GIDEVQFFDE NVVDIIEQLA DNGIIVIVNG LDKDFRGLPF KNVDKLLVKA 150
EFVTKLRARC HLCGSFANRS QRIVNGQPAL WDSPLILVDG KESYEARCRK 200
CFISPKKDV 209
Length:209
Mass (Da):23,820
Last modified:January 24, 2006 - v1
Checksum:i3570598B0F5A11E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000123 Genomic DNA. Translation: ABC01477.1.
RefSeqiWP_011387039.1. NC_007633.1.
YP_424134.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01477; ABC01477; MCAP_0143.
GeneIDi3828506.
KEGGimcp:MCAP_0143.
PATRICi20004745. VBIMycCap130493_0143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000123 Genomic DNA. Translation: ABC01477.1 .
RefSeqi WP_011387039.1. NC_007633.1.
YP_424134.1. NC_007633.1.

3D structure databases

ProteinModelPortali Q2SSX9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 340047.MCAP_0143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC01477 ; ABC01477 ; MCAP_0143 .
GeneIDi 3828506.
KEGGi mcp:MCAP_0143.
PATRICi 20004745. VBIMycCap130493_0143.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci MCAP340047:GC0H-142-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: California kid / ATCC 27343 / NCTC 10154.

Entry informationi

Entry nameiKITH_MYCCT
AccessioniPrimary (citable) accession number: Q2SSX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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