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Protein

Guanylate kinase

Gene

gmk

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:MCAP_0208
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001928 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002663501 – 297Guanylate kinaseAdd BLAST297

Proteomic databases

PRIDEiQ2SSR8.

Structurei

3D structure databases

ProteinModelPortaliQ2SSR8.
SMRiQ2SSR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 183Guanylate kinase-likeAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 297UnknownAdd BLAST94

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000037639.
KOiK00942.
OMAiFLMPPTL.
OrthoDBiPOG091H01Q4.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SSR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGKMIIIS GPSGVGKGSV NGELLQNPDL RLKYSVSMTT RKPRNGEING
60 70 80 90 100
VNYFFVSNEE FAKAIVNDEL IEYAHFVGNS YGTPRKYVEQ ELKKGNNVIL
110 120 130 140 150
EIEVDGATQV LNKEANVLSI FLMPPNLTEL ANRIRGRQTE DEEKIKARLD
160 170 180 190 200
KALLEIPLKH NYQYVIENDN VANAVAKITD VLHLEGLTDI KTPTVYERLE
210 220 230 240 250
QIVEQIVKEK YMYFVNNWET NVKLLAKNEE EKNKAKNFDA ETYLIKLLTK
260 270 280 290
KVYHKVLGHG DFSKLLDKDF VDFKIQKLMF KINFFSVEQK HYNNDEF
Length:297
Mass (Da):34,242
Last modified:January 24, 2006 - v1
Checksum:i9080733C7E435375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000123 Genomic DNA. Translation: ABC01818.1.
RefSeqiWP_011387096.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01818; ABC01818; MCAP_0208.
GeneIDi23778839.
KEGGimcp:MCAP_0208.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKGUA_MYCCT
AccessioniPrimary (citable) accession number: Q2SSR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families