Q2SSB6 (Q2SSB6_MYCCT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

MCAP_0363

Organism

Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) [Complete proteome] [HAMAP]

Taxonomic identifier

340047 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405 SAAS SAAS020922
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405 SAAS SAAS020922
Subunit structure	Homodimer By similarity. HAMAP MF_01405 SAAS SAAS020922
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405 RuleBase RU003781

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405 SAAS SAAS020922
Ligand	Magnesium HAMAP MF_01405 SAAS SAAS020922 Manganese HAMAP MF_01405 SAAS SAAS020922 Metal-binding HAMAP MF_01405 SAAS SAAS020922 Nucleotide-binding HAMAP MF_01405 SAAS SAAS020922
Molecular function	Hydrolase HAMAP MF_01405 SAAS SAAS020922 RuleBase RU003781
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	9 – 14	6	Substrate binding By similarity HAMAP MF_01405
	Region	69 – 70	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	40	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	69	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	158	1	Substrate By similarity HAMAP MF_01405
	Binding site	178	1	Substrate By similarity HAMAP MF_01405
	Binding site	184	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	Q2SSB6 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 38E7D54B287CC02F	FASTA	199	23,072
	10 20 30 40 50 60 MNKVIYLATT NKNKVKEFSE ILKGYQIKSL LDIPNYIEIE ENKKTFKQNA LLKAKHLAKY 70 80 90 100 110 120 INGIAIGDDT GICVKALNDF PGIYSKRWAY PLTNHYDICN KLLEKLKHIN QLHKRKAYMT 130 140 150 160 170 180 TAIALYDATT KKQFVYQSIA KGYIDFDIKK SDFGFGYDFI FIPKGYDKPY SLMSSELKNQ 190 ISARKKAIDR LIQYIDTVK

References

[1]	Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O., Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000123 Genomic DNA. Translation: ABC01103.1.
RefSeq	YP_424347.1. NC_007633.1.
3D structure databases
ProteinModelPortal	Q2SSB6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SSB6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3828319.
GenomeReviews	Gene locus MCAP_0363 in contig CP000123_GR.
KEGG	mcp:MCAP_0363.
PATRIC	20005199. VBIMycCap130493_0368.
TIGR	MCAP_0363.
Phylogenomic databases
eggNOG	COG0127.
HOGENOM	HBG697237.
OMA	ESSTRLT.
PhylomeDB	Q2SSB6.
ProtClustDB	CLSK745853.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2SSB6_MYCCT

Accession

Primary (citable) accession number: Q2SSB6

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)