pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
ATP-dependent 6-phosphofructokinase (pfkA)
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	277	Proton donorUniRule annotation	1
Active siteⁱ	298	UniRule annotation	1
Active siteⁱ	414	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCycⁱ	MCAP340047:G1G57-467-MONOMER
UniPathwayⁱ	UPA00109; UER00181 UPA00138

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:MCAP_0465
Organismⁱ	Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifierⁱ	340047 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma mycoides group › Mycoplasma capricolum › Mycoplasma capricolum subsp. capricolum
Proteomesⁱ	UP000001928 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000230920	1 – 427	Glucose-6-phosphate isomeraseAdd BLAST		427

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2SS24
SMRⁱ	Q2SS24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000100403
KEGG Orthology (KO) More...KOⁱ	K01810
OMAⁱ	SFIIPDD
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0EIM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit
HAMAPⁱ	MF_00473 G6P_isomerase, 1 hit
InterProⁱ	View protein in InterPro IPR001672 G6P_Isomerase IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2
PANTHERⁱ	PTHR11469 PTHR11469, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342 PGI, 1 hit
PRINTSⁱ	PR00662 G6PISOMERASE
PROSITEⁱ	View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q2SS24-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIKVNLDHTD ININKVADLN KIKEIHQMIF NKTGKGNDFL GWLNWPVNFN 
        60         70         80         90        100
KTEYEQMKLV ANDLKNQIEV LVVIGIGGSY LGCRAADEMI RGLYHQNKVE 
       110        120        130        140        150
LIYTGNTMSS TYIYQVVEYL KNKNFGICVI SKSGTTTEPG ISFRVFEKLL 
       160        170        180        190        200
VDKVGLEKAK SLIVAITDKN KGALKQLAEK KGYQTFVIPN DIGGRFSVLT 
       210        220        230        240        250
PVGIFPLLVS GINTDKIFQG ALKAKNDLIN DDLSNQAYKY AVVRNYLYNQ 
       260        270        280        290        300
GYKTEALISY ELQLQMLTEW WKQLFGESEG KENKGLLPSS MIFSTDLHSL 
       310        320        330        340        350
GQWVQEGPRN VMFETIIKIE KPNHDLNVPI DEDNYDGLNY LTKKSFHQIN 
       360        370        380        390        400
QTALKGVIQA HSVTGKMPNI VLEFEKMDDE QFGYLVYFFE LALAMSAYLL 
       410        420 
DVNPFNQPGV EVYKYNMFKL LNKPGIK

Length:427

Mass (Da):48,526

Last modified:January 24, 2006 - v1

Checksum:ⁱD1CAE9A23AF8BCA0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000123 Genomic DNA Translation: ABC01694.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011387338.1, NC_007633.1

Genome annotation databases

EnsemblBacteriaⁱ	ABC01694; ABC01694; MCAP_0465
GeneIDⁱ	23778579
KEGGⁱ	mcp:MCAP_0465

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q2SS24	I1XDC3 I1XDA4 I1XDA2	Mycoplasma capricolum subsp. capripneumoniae Mycoplasma capricolum subsp. capricolum Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)	427	UniRef100_Q2SS24	Cluster: Glucose-6-phosphate isomerase	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q2SS24	I1XDC3 I1XDA4 I1XDA2 Q6MTA3 A0A0F2BIN6 I1XDJ4 A0A0C2ZMV1 A0A1D5B4S2 A0A078MZ73 E4PU87 +11	Mycoplasma capricolum subsp. capripneumoniae Mycoplasma capricolum subsp. capricolum Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) Mycoplasma mycoides subsp. mycoides SC (strain PG1) Mycoplasma mycoides subsp. mycoides Mycoplasma capricolum subsp. capripneumoniae 87001 Mycoplasma leachii (strain DSM 21131 / NCTC 10133 / N29 / PG50) Mycoplasma leachii Mycoplasma mycoides subsp. capri LC str. 95010 Mycoplasma mycoides subsp. capri And more	427	UniRef90_Q2SS24	Cluster: Glucose-6-phosphate isomerase	22

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q2SS24	Q6KH90 R4UA58 R4UI25 S5M0G7 A0A235CQC0 UPI000C6C91FA UPI0004805009 C4XFD5 R5PR16 W6A826 +30	Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711) Spiroplasma chrysopicola DF-1 Spiroplasma syrphidicola EA-1 Spiroplasma taiwanense CT-1 Mycoplasma testudineum Centruroides sculpturatus (Bark scorpion) Entomoplasma lucivorax Mycoplasma fermentans (strain ATCC 19989 / NBRC 14854 / NCTC 10117 / PG18) Clostridium sp. CAG:780 Spiroplasma culicicola AES-1 And more	433	UniRef50_Q6KH90	Cluster: Glucose-6-phosphate isomerase	41

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000123 Genomic DNA Translation: ABC01694.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011387338.1, NC_007633.1

3D structure databases

ProteinModelPortalⁱ	Q2SS24
SMRⁱ	Q2SS24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABC01694; ABC01694; MCAP_0465
GeneIDⁱ	23778579
KEGGⁱ	mcp:MCAP_0465

Phylogenomic databases

HOGENOMⁱ	HOG000100403
KEGG Orthology (KO) More...KOⁱ	K01810
OMAⁱ	SFIIPDD
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0EIM

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181 UPA00138
BioCycⁱ	MCAP340047:G1G57-467-MONOMER

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015 SIS_PGI_1, 1 hit cd05016 SIS_PGI_2, 1 hit
HAMAPⁱ	MF_00473 G6P_isomerase, 1 hit
InterProⁱ	View protein in InterPro IPR001672 G6P_Isomerase IPR018189 Phosphoglucose_isomerase_CS IPR035476 SIS_PGI_1 IPR035482 SIS_PGI_2
PANTHERⁱ	PTHR11469 PTHR11469, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342 PGI, 1 hit
PRINTSⁱ	PR00662 G6PISOMERASE
PROSITEⁱ	View protein in PROSITE PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_MYCCT
Accessionⁱ	Q2SS24Primary (citable) accession number: Q2SS24
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
	Last sequence update:	January 24, 2006
	Last modified:	February 28, 2018
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q2SS24 (G6PI_MYCCT)

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ