pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
ATP-dependent 6-phosphofructokinase (pfkA)
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	Length	Description
Active siteⁱ	277 – 277	1	Proton donorUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473
Active siteⁱ	298 – 298	1	UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473
Active siteⁱ	414 – 414	1	UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-HAMAP
glycolytic process Source: UniProtKB-HAMAP

Complete GO annotation...

Keywords - Molecular functionⁱ

Isomerase

Keywords - Biological processⁱ

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCycⁱ	MCAP340047:GC0H-462-MONOMER.
UniPathwayⁱ	UPA00109; UER00181. UPA00138.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 (EC:5.3.1.9UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 ) Short name: GPIUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 Alternative name(s): Phosphoglucose isomeraseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 Short name: PGIUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 Phosphohexose isomeraseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 Short name: PHIUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473
Gene namesⁱ	Name:pgiUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00473 Ordered Locus Names:MCAP_0465
Organismⁱ	Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifierⁱ	340047 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma mycoides group › Mycoplasma capricolum › Mycoplasma capricolum subsp. capricolum
Proteomesⁱ	UP000001928 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 427	427	Glucose-6-phosphate isomerase		PRO_0000230920	Add BLAST

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2SS24.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000100403.
KOⁱ	K01810.
OMAⁱ	FGYFYFW.
OrthoDBⁱ	POG091H0EIM.

Family and domain databases

HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfamⁱ	PF00342. PGI. 1 hit. [Graphical view]
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q2SS24-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIKVNLDHTD ININKVADLN KIKEIHQMIF NKTGKGNDFL GWLNWPVNFN 
        60         70         80         90        100
KTEYEQMKLV ANDLKNQIEV LVVIGIGGSY LGCRAADEMI RGLYHQNKVE 
       110        120        130        140        150
LIYTGNTMSS TYIYQVVEYL KNKNFGICVI SKSGTTTEPG ISFRVFEKLL 
       160        170        180        190        200
VDKVGLEKAK SLIVAITDKN KGALKQLAEK KGYQTFVIPN DIGGRFSVLT 
       210        220        230        240        250
PVGIFPLLVS GINTDKIFQG ALKAKNDLIN DDLSNQAYKY AVVRNYLYNQ 
       260        270        280        290        300
GYKTEALISY ELQLQMLTEW WKQLFGESEG KENKGLLPSS MIFSTDLHSL 
       310        320        330        340        350
GQWVQEGPRN VMFETIIKIE KPNHDLNVPI DEDNYDGLNY LTKKSFHQIN 
       360        370        380        390        400
QTALKGVIQA HSVTGKMPNI VLEFEKMDDE QFGYLVYFFE LALAMSAYLL 
       410        420 
DVNPFNQPGV EVYKYNMFKL LNKPGIK

Length:427

Mass (Da):48,526

Last modified:January 24, 2006 - v1

Checksum:ⁱD1CAE9A23AF8BCA0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000123 Genomic DNA. Translation: ABC01694.1.
RefSeqⁱ	WP_011387338.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABC01694; ABC01694; MCAP_0465.
GeneIDⁱ	23778579.
KEGGⁱ	mcp:MCAP_0465.
PATRICⁱ	20005401. VBIMycCap130493_0461.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000123 Genomic DNA. Translation: ABC01694.1.
RefSeqⁱ	WP_011387338.1. NC_007633.1.

3D structure databases

ProteinModelPortalⁱ	Q2SS24.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABC01694; ABC01694; MCAP_0465.
GeneIDⁱ	23778579.
KEGGⁱ	mcp:MCAP_0465.
PATRICⁱ	20005401. VBIMycCap130493_0461.

Phylogenomic databases

HOGENOMⁱ	HOG000100403.
KOⁱ	K01810.
OMAⁱ	FGYFYFW.
OrthoDBⁱ	POG091H0EIM.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.
BioCycⁱ	MCAP340047:GC0H-462-MONOMER.

Family and domain databases

HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfamⁱ	PF00342. PGI. 1 hit. [Graphical view]
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

G6PI_MYCCT

Accessionⁱ

Primary (citable) accession number: Q2SS24

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 24, 2006
Last modified:	September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q2SS24 (G6PI_MYCCT)

UniProt

Q2SS24 - G6PI_MYCCT

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>Describes the metabolic pathway(s) associated with a protein.</p><p><a href='../manual/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>Describes the metabolic pathway(s) associated with a protein.</p><p><a href='../manual/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ