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Q2SRJ4 (PTC_MYCCT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putrescine carbamoyltransferase
Short name=PTC
Short name=PTCase
EC=2.1.3.6
Alternative name(s):
Putrescine transcarbamoylase
Putrescine transcarbamylase
Gene names
Name:ptcA
Synonyms:argF
Ordered Locus Names:MCAP_0654
OrganismMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) [Complete proteome] [HAMAP]
Taxonomic identifier340047 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine By similarity. HAMAP-Rule MF_02102

Catalytic activity

Carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine. HAMAP-Rule MF_02102

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1. HAMAP-Rule MF_02102

Subunit structure

Homotrimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ATCase/OTCase family. PTCase subfamily.

Ontologies

Keywords
   Biological processPolyamine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processputrescine biosynthetic process from arginine via N-carbamoylputrescine

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionamino acid binding

Inferred from electronic annotation. Source: InterPro

putrescine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Putrescine carbamoyltransferase HAMAP-Rule MF_02102
PRO_0000380721

Regions

Region54 – 585Carbamoyl phosphate binding By similarity
Region277 – 2804Putrescine binding By similarity

Sites

Binding site1051Carbamoyl phosphate By similarity
Binding site1321Carbamoyl phosphate By similarity
Site291Important for structural integrity By similarity
Site1451Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2SRJ4 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: CE6D8DDFE4924385

FASTA36542,318
        10         20         30         40         50         60 
MNKVRHFIDT QDLSKKEIFE IFRLMKMLKE ARYCGAVPEL LKNKTLAMIF EEPSTRTRVS 

        70         80         90        100        110        120 
FEAAMTLLGG HAQYLKPGEL HLGVRESLYD TTKVLSHMCD GIMCRALKHE TVLNLAKYAD 

       130        140        150        160        170        180 
VPVLNGLTDY NHPTQAICDV FTMLEYMPAT KNLEYEDIKF EDIKVVFIGD RTNVCSSTMH 

       190        200        210        220        230        240 
ITTKLGMNFV HISPKRYQSP QEWVDIANEN IKQANSGSVL VTDDLEQVKD ADIVYTDLWW 

       250        260        270        280        290        300 
WVDQEDEAEE RVKAFKPTYQ VTPELMKKAG QQALFMHCLP ASRNVEVYDE VIDSDQSIAF 

       310        320        330        340        350        360 
EQAENRLTAQ MGLLVYYLYP QIDKSSNAVK DYYRGKVEAF MEHQDRSWKQ RYTYNNDYAE 


TKNKK

« Hide

References

[1]Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O., Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: California kid / ATCC 27343 / NCTC 10154.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000123 Genomic DNA. Translation: ABC01353.1.
RefSeqYP_424619.1. NC_007633.1.

3D structure databases

HSSPHSSP built from PDB template 1VLV based on UniProtKB P96108.
ProteinModelPortalQ2SRJ4.
ModBaseSearch...

Protein-protein interaction databases

STRING340047.MCAP_0654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC01353; ABC01353; MCAP_0654.
GeneID3828588.
KEGGmcp:MCAP_0654.
PATRIC20005785. VBIMycCap130493_0648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0078.
HOGENOMHOG000022686.
KOK13252.
OMAAHPCQTL.
ProtClustDBPRK02255.

Enzyme and pathway databases

UniPathwayUPA00534; UER00941.

Family and domain databases

HAMAPMF_02102. PTCase.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024903. PtcA.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTC_MYCCT
AccessionPrimary (citable) accession number: Q2SRJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 24, 2006
Last modified: May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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