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Q2SRI9

- SYL_MYCCT

UniProt

Q2SRI9 - SYL_MYCCT

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMCAP340047:GC0H-656-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MCAP_0659
    OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
    Taxonomic identifieri340047 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001928: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_1000009374Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340047.MCAP_0659.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2SRI9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2SRI9-1 [UniParc]FASTAAdd to Basket

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    MDFSHKAIEK KWQKYWKENN VYKTTDSNHK KAYVLDMFPY PSGAGLHVGH    50
    IKGYTATDVY SRFKRMQGYD VLHPIGWDAF GLPAEQYALK TGNDPRDFTL 100
    KNIENFKAQL VKMGFSYDYD KEINTADPNY YKVTQWIFKE LYKKGLAENR 150
    NIDVNWCQEL GTVLANDEII EKDGLMVSER GEYPVVKKKM RQWVLKITDY 200
    ADKLLKGLDN LDWPNSVKEL QRNWIGKSEG CEINFKSNDI NIPVFTTRAD 250
    TVFGATYIVL APENELVLKL TTPNKLDEVK KYIELTANKS EIERKDESKT 300
    KTGVFIGSYA INPLTKEQIQ IWISDYVLND YGSGAIMAVP AHDKRDWDFA 350
    TKFNLPIRFV ISTKDESKAF VGEGKHINSE FLNDLDRIQS LQVIHDYIEK 400
    NNLGKKKTNY KLRDWLFSRQ RFYGEPFPVL YDKDNNIILV EDDDLPITLP 450
    KTDYIKPTNT GESPLANVKN WVNVKIGDRE YKRETNTMPQ SAGSSWYFIA 500
    YILANSKNNL IDLTSDEAKK RLEKWLPVDL YIGGQEHAVG HLLYSRFWTH 550
    FLYDLGLLPT SEPFQRLFNQ GMILGPDNRK MSKSWGNVIN PDDVIDTHGA 600
    DALRLYEMFM GPLDASLPWS FDGLDASLKW LNRCYRMINK IEFSNTNNHK 650
    LDYVYNDVVK KVTQMITELK FNTAISQLMV LVNAIYKEEL STVYKPYIEG 700
    FVKMLSLFSP HLAEELWEKL GNNSSVTLQA WPEFDETKIV KNTVVIALQV 750
    NGKLRSTIEV EKGTDKETLI KLAQENENII RFIKGHKNLK YIAVVDRIVN 800
    IVIE 804
    Length:804
    Mass (Da):92,983
    Last modified:January 24, 2006 - v1
    Checksum:iC96DDA009800B974
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000123 Genomic DNA. Translation: ABC01150.1.
    RefSeqiWP_011387520.1. NC_007633.1.
    YP_424624.1. NC_007633.1.

    Genome annotation databases

    EnsemblBacteriaiABC01150; ABC01150; MCAP_0659.
    GeneIDi3828466.
    KEGGimcp:MCAP_0659.
    PATRICi20005795. VBIMycCap130493_0653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000123 Genomic DNA. Translation: ABC01150.1 .
    RefSeqi WP_011387520.1. NC_007633.1.
    YP_424624.1. NC_007633.1.

    3D structure databases

    ProteinModelPortali Q2SRI9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340047.MCAP_0659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC01150 ; ABC01150 ; MCAP_0659 .
    GeneIDi 3828466.
    KEGGi mcp:MCAP_0659.
    PATRICi 20005795. VBIMycCap130493_0653.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MCAP340047:GC0H-656-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: California kid / ATCC 27343 / NCTC 10154.

    Entry informationi

    Entry nameiSYL_MYCCT
    AccessioniPrimary (citable) accession number: Q2SRI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3