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Q2SRI9

- SYL_MYCCT

UniProt

Q2SRI9 - SYL_MYCCT

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCAP340047:GC0H-656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MCAP_0659
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001928: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligasePRO_1000009374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340047.MCAP_0659.

Structurei

3D structure databases

ProteinModelPortaliQ2SRI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 5012"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVNIVTND.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SRI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFSHKAIEK KWQKYWKENN VYKTTDSNHK KAYVLDMFPY PSGAGLHVGH
60 70 80 90 100
IKGYTATDVY SRFKRMQGYD VLHPIGWDAF GLPAEQYALK TGNDPRDFTL
110 120 130 140 150
KNIENFKAQL VKMGFSYDYD KEINTADPNY YKVTQWIFKE LYKKGLAENR
160 170 180 190 200
NIDVNWCQEL GTVLANDEII EKDGLMVSER GEYPVVKKKM RQWVLKITDY
210 220 230 240 250
ADKLLKGLDN LDWPNSVKEL QRNWIGKSEG CEINFKSNDI NIPVFTTRAD
260 270 280 290 300
TVFGATYIVL APENELVLKL TTPNKLDEVK KYIELTANKS EIERKDESKT
310 320 330 340 350
KTGVFIGSYA INPLTKEQIQ IWISDYVLND YGSGAIMAVP AHDKRDWDFA
360 370 380 390 400
TKFNLPIRFV ISTKDESKAF VGEGKHINSE FLNDLDRIQS LQVIHDYIEK
410 420 430 440 450
NNLGKKKTNY KLRDWLFSRQ RFYGEPFPVL YDKDNNIILV EDDDLPITLP
460 470 480 490 500
KTDYIKPTNT GESPLANVKN WVNVKIGDRE YKRETNTMPQ SAGSSWYFIA
510 520 530 540 550
YILANSKNNL IDLTSDEAKK RLEKWLPVDL YIGGQEHAVG HLLYSRFWTH
560 570 580 590 600
FLYDLGLLPT SEPFQRLFNQ GMILGPDNRK MSKSWGNVIN PDDVIDTHGA
610 620 630 640 650
DALRLYEMFM GPLDASLPWS FDGLDASLKW LNRCYRMINK IEFSNTNNHK
660 670 680 690 700
LDYVYNDVVK KVTQMITELK FNTAISQLMV LVNAIYKEEL STVYKPYIEG
710 720 730 740 750
FVKMLSLFSP HLAEELWEKL GNNSSVTLQA WPEFDETKIV KNTVVIALQV
760 770 780 790 800
NGKLRSTIEV EKGTDKETLI KLAQENENII RFIKGHKNLK YIAVVDRIVN

IVIE
Length:804
Mass (Da):92,983
Last modified:January 24, 2006 - v1
Checksum:iC96DDA009800B974
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000123 Genomic DNA. Translation: ABC01150.1.
RefSeqiWP_011387520.1. NC_007633.1.
YP_424624.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01150; ABC01150; MCAP_0659.
GeneIDi3828466.
KEGGimcp:MCAP_0659.
PATRICi20005795. VBIMycCap130493_0653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000123 Genomic DNA. Translation: ABC01150.1 .
RefSeqi WP_011387520.1. NC_007633.1.
YP_424624.1. NC_007633.1.

3D structure databases

ProteinModelPortali Q2SRI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340047.MCAP_0659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC01150 ; ABC01150 ; MCAP_0659 .
GeneIDi 3828466.
KEGGi mcp:MCAP_0659.
PATRICi 20005795. VBIMycCap130493_0653.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VNIVTND.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MCAP340047:GC0H-656-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: California kid / ATCC 27343 / NCTC 10154.

Entry informationi

Entry nameiSYL_MYCCT
AccessioniPrimary (citable) accession number: Q2SRI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3