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Q2SRA2

- TRMB_MYCCT

UniProt

Q2SRA2 - TRMB_MYCCT

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421S-adenosyl-L-methionineUniRule annotation
Binding sitei67 – 671S-adenosyl-L-methionineUniRule annotation
Active sitei122 – 1221By similarity
Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMCAP340047:GC0H-758-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:MCAP_0761
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001928: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220tRNA (guanine-N(7)-)-methyltransferasePRO_0000229173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340047.MCAP_0761.

Structurei

3D structure databases

ProteinModelPortaliQ2SRA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 2014Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiINYLEAT.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SRA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLRKKAWTN EFLNQHTYYL IKYDKKINLN EIFLNNNPTC LEIGCGKGQF
60 70 80 90 100
LTTLALKNPN LNYIGMEKSS TITAIGLKKS LKEFQNNSKK MTNIKYLNKY
110 120 130 140 150
AENLLEIFYT DSFSRIYLNF SDPWPKARHY KKRLTYLGFL DIYSDILIKN
160 170 180 190 200
GFLEFKTDND SLYNFTLEQL KLTNKWEIIS NTLDLYNDQE LLKDNVPTEY
210 220
ETKFHLANKN IYKIVIKNLK
Length:220
Mass (Da):26,151
Last modified:January 24, 2006 - v1
Checksum:iA6C7373705FAE14B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000123 Genomic DNA. Translation: ABC01304.1.
RefSeqiWP_011387595.1. NC_007633.1.
YP_424711.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01304; ABC01304; MCAP_0761.
GeneIDi3828895.
KEGGimcp:MCAP_0761.
PATRICi20005999. VBIMycCap130493_0741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000123 Genomic DNA. Translation: ABC01304.1 .
RefSeqi WP_011387595.1. NC_007633.1.
YP_424711.1. NC_007633.1.

3D structure databases

ProteinModelPortali Q2SRA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340047.MCAP_0761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC01304 ; ABC01304 ; MCAP_0761 .
GeneIDi 3828895.
KEGGi mcp:MCAP_0761.
PATRICi 20005999. VBIMycCap130493_0741.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi INYLEAT.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MCAP340047:GC0H-758-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: California kid / ATCC 27343 / NCTC 10154.

Entry informationi

Entry nameiTRMB_MYCCT
AccessioniPrimary (citable) accession number: Q2SRA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3