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Q2SRA2

- TRMB_MYCCT

UniProt

Q2SRA2 - TRMB_MYCCT

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, MCAP_0761
Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421S-adenosyl-L-methionine By similarity
Binding sitei67 – 671S-adenosyl-L-methionine By similarity
Active sitei122 – 1221 By similarity
Binding sitei122 – 1221S-adenosyl-L-methionine By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei158 – 1581Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMCAP340047:GC0H-758-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MCAP_0761
OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Taxonomic identifieri340047 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001928: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000229173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340047.MCAP_0761.

Structurei

3D structure databases

ProteinModelPortaliQ2SRA2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 2014Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiINYLEAT.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SRA2-1 [UniParc]FASTAAdd to Basket

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MRLRKKAWTN EFLNQHTYYL IKYDKKINLN EIFLNNNPTC LEIGCGKGQF    50
LTTLALKNPN LNYIGMEKSS TITAIGLKKS LKEFQNNSKK MTNIKYLNKY 100
AENLLEIFYT DSFSRIYLNF SDPWPKARHY KKRLTYLGFL DIYSDILIKN 150
GFLEFKTDND SLYNFTLEQL KLTNKWEIIS NTLDLYNDQE LLKDNVPTEY 200
ETKFHLANKN IYKIVIKNLK 220
Length:220
Mass (Da):26,151
Last modified:January 24, 2006 - v1
Checksum:iA6C7373705FAE14B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000123 Genomic DNA. Translation: ABC01304.1.
RefSeqiWP_011387595.1. NC_007633.1.
YP_424711.1. NC_007633.1.

Genome annotation databases

EnsemblBacteriaiABC01304; ABC01304; MCAP_0761.
GeneIDi3828895.
KEGGimcp:MCAP_0761.
PATRICi20005999. VBIMycCap130493_0741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000123 Genomic DNA. Translation: ABC01304.1 .
RefSeqi WP_011387595.1. NC_007633.1.
YP_424711.1. NC_007633.1.

3D structure databases

ProteinModelPortali Q2SRA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340047.MCAP_0761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC01304 ; ABC01304 ; MCAP_0761 .
GeneIDi 3828895.
KEGGi mcp:MCAP_0761.
PATRICi 20005999. VBIMycCap130493_0741.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi INYLEAT.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MCAP340047:GC0H-758-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: California kid / ATCC 27343 / NCTC 10154.

Entry informationi

Entry nameiTRMB_MYCCT
AccessioniPrimary (citable) accession number: Q2SRA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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