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Q2SRA2

- TRMB_MYCCT

UniProt

Q2SRA2 - TRMB_MYCCT

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421S-adenosyl-L-methionineUniRule annotation
    Binding sitei67 – 671S-adenosyl-L-methionineUniRule annotation
    Active sitei122 – 1221By similarity
    Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMCAP340047:GC0H-758-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:MCAP_0761
    OrganismiMycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
    Taxonomic identifieri340047 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001928: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220tRNA (guanine-N(7)-)-methyltransferasePRO_0000229173Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340047.MCAP_0761.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2SRA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni198 – 2014Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiINYLEAT.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2SRA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLRKKAWTN EFLNQHTYYL IKYDKKINLN EIFLNNNPTC LEIGCGKGQF    50
    LTTLALKNPN LNYIGMEKSS TITAIGLKKS LKEFQNNSKK MTNIKYLNKY 100
    AENLLEIFYT DSFSRIYLNF SDPWPKARHY KKRLTYLGFL DIYSDILIKN 150
    GFLEFKTDND SLYNFTLEQL KLTNKWEIIS NTLDLYNDQE LLKDNVPTEY 200
    ETKFHLANKN IYKIVIKNLK 220
    Length:220
    Mass (Da):26,151
    Last modified:January 24, 2006 - v1
    Checksum:iA6C7373705FAE14B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000123 Genomic DNA. Translation: ABC01304.1.
    RefSeqiWP_011387595.1. NC_007633.1.
    YP_424711.1. NC_007633.1.

    Genome annotation databases

    EnsemblBacteriaiABC01304; ABC01304; MCAP_0761.
    GeneIDi3828895.
    KEGGimcp:MCAP_0761.
    PATRICi20005999. VBIMycCap130493_0741.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000123 Genomic DNA. Translation: ABC01304.1 .
    RefSeqi WP_011387595.1. NC_007633.1.
    YP_424711.1. NC_007633.1.

    3D structure databases

    ProteinModelPortali Q2SRA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340047.MCAP_0761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC01304 ; ABC01304 ; MCAP_0761 .
    GeneIDi 3828895.
    KEGGi mcp:MCAP_0761.
    PATRICi 20005999. VBIMycCap130493_0741.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi INYLEAT.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MCAP340047:GC0H-758-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: California kid / ATCC 27343 / NCTC 10154.

    Entry informationi

    Entry nameiTRMB_MYCCT
    AccessioniPrimary (citable) accession number: Q2SRA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3