Q2SLW3 (ADE_HAHCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

HCH_01503

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Adenine deaminase HAMAP MF_01962		PRO_1000017663
Sites
	Active site	197	1	Proton donor By similarity
	Metal binding	14	1	Zinc; catalytic By similarity
	Metal binding	16	1	Zinc; catalytic By similarity
	Metal binding	194	1	Zinc; catalytic By similarity
	Metal binding	275	1	Zinc; catalytic By similarity
	Binding site	276	1	Substrate By similarity
	Site	218	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SLW3 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: C4379DD26145913A	FASTA	334	38,111
	10 20 30 40 50 60 MQDFLKGLPK AELHLHIEGS LEPELMFEIG RRNGVALPFA NVEEVRAAYE FNNLQEFLDI 70 80 90 100 110 120 YYQGAQVLLH EQDFYDMTFA YLQRCREQNV IHAEMFFDPQ THTDRGVDIG VVIRGLTRAM 130 140 150 160 170 180 EDAEIQWGQS SKLILCFLRH LSEDAAIETL RQALPYKQHF VGVGLDSSEV GHPPEKFQRV 190 200 210 220 230 240 FEQAQNAGLL TVAHAGEEGP PEYIWQALDL LKVKRIDHGV RCIEDAALMQ RLIDEQIPLT 250 260 270 280 290 300 VCPLSNIKLC VFDSMSEHNI LRLLEKGLKV TVNSDDPAYF GGYMNENFIA MQEALPMSKE 310 320 330 QAAQLARNSF EASFLTSEEK ARLLARLDQY LQNH

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KCTC 2396.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000155 Genomic DNA. Translation: ABC28361.1.
RefSeq	YP_432786.1. NC_007645.1.
3D structure databases
ProteinModelPortal	Q2SLW3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SLW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3838829.
GenomeReviews	Gene locus HCH_01503 in contig CP000155_GR.
KEGG	hch:HCH_01503.
NMPDR	fig|349521.5.peg.1353.
PATRIC	22083966. VBIHahChe29232_1389.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	ENFHALY.
PhylomeDB	Q2SLW3.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_01503-MONOMER.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_HAHCH

Accession

Primary (citable) accession number: Q2SLW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program