Reviewed, UniProtKB/Swiss-Prot Q2SLW3 (ADD_HAHCH)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	HCH_01503

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Adenosine deaminase HAMAP MF_00540		PRO_1000017663
Sites
	Active site	194	1	Potential
	Active site	242	1	Potential
	Active site	275	1	Potential
	Active site	276	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2SLW3-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: C4379DD26145913A	FASTA	334	38,111
	10 20 30 40 50 60 MQDFLKGLPK AELHLHIEGS LEPELMFEIG RRNGVALPFA NVEEVRAAYE FNNLQEFLDI 70 80 90 100 110 120 YYQGAQVLLH EQDFYDMTFA YLQRCREQNV IHAEMFFDPQ THTDRGVDIG VVIRGLTRAM 130 140 150 160 170 180 EDAEIQWGQS SKLILCFLRH LSEDAAIETL RQALPYKQHF VGVGLDSSEV GHPPEKFQRV 190 200 210 220 230 240 FEQAQNAGLL TVAHAGEEGP PEYIWQALDL LKVKRIDHGV RCIEDAALMQ RLIDEQIPLT 250 260 270 280 290 300 VCPLSNIKLC VFDSMSEHNI LRLLEKGLKV TVNSDDPAYF GGYMNENFIA MQEALPMSKE 310 320 330 QAAQLARNSF EASFLTSEEK ARLLARLDQY LQNH

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000155 Genomic DNA. Translation: ABC28361.1.
RefSeq	YP_432786.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3838829.
GenomeReviews	Gene locus HCH_01503 in contig CP000155_GR.
KEGG	hch:HCH_01503.
NMPDR	fig|349521.5.peg.1353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2SLW3.
OMA	Q2SLW3. LAQNSLD.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_01503-MON.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_HAHCH

Accession

Primary (citable) accession number: Q2SLW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)