ID   SAHH_HAHCH              Reviewed;         463 AA.
AC   Q2SLT4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Adenosylhomocysteinase;
DE            EC=3.3.1.1;
DE   AltName: Full=S-adenosyl-L-homocysteine hydrolase;
DE            Short=AdoHcyase;
GN   Name=ahcY; OrderedLocusNames=HCH_01532;
OS   Hahella chejuensis (strain KCTC 2396).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Hahellaceae; Hahella.
OX   NCBI_TaxID=349521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16352867; DOI=10.1093/nar/gki1016;
RA   Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H.,
RA   Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H.,
RA   Park H.-S., Lee H.K., Oh T.K., Kim J.F.;
RT   "Genomic blueprint of Hahella chejuensis, a marine microbe producing
RT   an algicidal agent.";
RL   Nucleic Acids Res. 33:7066-7073(2005).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-
CC       homocysteine + adenosine.
CC   -!- COFACTOR: Binds 1 NAD per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; homocysteine biosynthesis; L-
CC       homocysteine from S-adenosyl-L-homocysteine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
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DR   EMBL; CP000155; ABC28390.1; -; Genomic_DNA.
DR   RefSeq; YP_432815.1; -.
DR   GeneID; 3837562; -.
DR   GenomeReviews; CP000155_GR; HCH_01532.
DR   KEGG; hch:HCH_01532; -.
DR   NMPDR; fig|349521.5.peg.1378; -.
DR   HOGENOM; Q2SLT4; -.
DR   OMA; Q2SLT4; HMRAMKD.
DR   BioCyc; HCHE349521:HCH_01532-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004013; F:adenosylhomocysteinase activity; IEA:HAMAP.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00563; -; 1.
DR   InterPro; IPR000043; Ad_hcy_hydrolase.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   Gene3D; G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
DR   PANTHER; PTHR23420; Ad_hcy_hydrolase; 1.
DR   Pfam; PF05221; AdoHcyase; 1.
DR   Pfam; PF00670; AdoHcyase_NAD; 1.
DR   PIRSF; PIRSF001109; Ad_hcy_hydrolase; 1.
DR   TIGRFAMs; TIGR00936; ahcY; 1.
DR   PROSITE; PS00738; ADOHCYASE_1; 1.
DR   PROSITE; PS00739; ADOHCYASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
FT   CHAIN         1    463       Adenosylhomocysteinase.
FT                                /FTId=PRO_1000024728.
FT   REGION      191    373       NAD binding (By similarity).
FT   BINDING      63     63       Substrate (By similarity).
FT   BINDING     139    139       Substrate (By similarity).
FT   BINDING     164    164       Substrate (By similarity).
FT   BINDING     194    194       Substrate (By similarity).
FT   BINDING     198    198       Substrate (By similarity).
SQ   SEQUENCE   463 AA;  51348 MW;  40D703C8EAE28FF6 CRC64;
     MAQLQSVDNF SDYKVKDISL AAWGRKEIDI AEGEMPALMT LREKYRAQQP LAGARILGCI
     HMTIQTAVLI ETLVALGAEV RWSSCNIFST QDHAAAAIAA AGVPVFAWKG ETEEEYVWCI
     KQTITKDGQP WNANMVLDDG GDLTEILHNE FPQMLDHIHG ISEETTTGVH RLLDMMKKGE
     LKVPAVNVND SVTKSKNDNK YGCRHSLNDA IKRATDHLLA GKKALVIGYG DVGKGSAASL
     RQEGMIVKIS EIDPICAMQA CMDGYEVVSP YIDGVNTGAA DGVNRDLLGH TDLLVTTTGN
     VNVCDKYMLQ ALKSGAVVCN IGHFDNEIDT RFMRDNWEWE EVKPQVHVIY RNKDQNDHLL
     LLSEGRLVNL GNATGHPSRI MDGSFANQVL AQMYLFERKF ADLPADEKPK NLYVRVLPKQ
     LDEEVARYMV QGFGGVITKL TQPQAKYIGV EVEGPYKPTD YKY
//