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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Substrate1
Binding sitei139Substrate1
Binding sitei164Substrate1
Binding sitei194Substrate1
Binding sitei198Substrate1
Binding sitei199NAD1
Binding sitei251NAD1
Binding sitei300NAD1
Binding sitei369NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 167NAD3
Nucleotide bindingi228 – 233NAD6
Nucleotide bindingi321 – 323NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:HCH_01532
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000247281 – 463AdenosylhomocysteinaseAdd BLAST463

Proteomic databases

PRIDEiQ2SLT4.

Interactioni

Protein-protein interaction databases

STRINGi349521.HCH_01532.

Structurei

3D structure databases

ProteinModelPortaliQ2SLT4.
SMRiQ2SLT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SLT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLQSVDNF SDYKVKDISL AAWGRKEIDI AEGEMPALMT LREKYRAQQP
60 70 80 90 100
LAGARILGCI HMTIQTAVLI ETLVALGAEV RWSSCNIFST QDHAAAAIAA
110 120 130 140 150
AGVPVFAWKG ETEEEYVWCI KQTITKDGQP WNANMVLDDG GDLTEILHNE
160 170 180 190 200
FPQMLDHIHG ISEETTTGVH RLLDMMKKGE LKVPAVNVND SVTKSKNDNK
210 220 230 240 250
YGCRHSLNDA IKRATDHLLA GKKALVIGYG DVGKGSAASL RQEGMIVKIS
260 270 280 290 300
EIDPICAMQA CMDGYEVVSP YIDGVNTGAA DGVNRDLLGH TDLLVTTTGN
310 320 330 340 350
VNVCDKYMLQ ALKSGAVVCN IGHFDNEIDT RFMRDNWEWE EVKPQVHVIY
360 370 380 390 400
RNKDQNDHLL LLSEGRLVNL GNATGHPSRI MDGSFANQVL AQMYLFERKF
410 420 430 440 450
ADLPADEKPK NLYVRVLPKQ LDEEVARYMV QGFGGVITKL TQPQAKYIGV
460
EVEGPYKPTD YKY
Length:463
Mass (Da):51,348
Last modified:January 24, 2006 - v1
Checksum:i40D703C8EAE28FF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC28390.1.
RefSeqiWP_011395463.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC28390; ABC28390; HCH_01532.
KEGGihch:HCH_01532.

Similar proteinsi

Entry informationi

Entry nameiSAHH_HAHCH
AccessioniPrimary (citable) accession number: Q2SLT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families