Q2SL19 (UPPP_HAHCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	HCH_01816

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella › Hahella chejuensis

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000250238
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	217 – 237	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2SL19 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 5E3C68A792B53439	FASTA	266	28,588
	10 20 30 40 50 60 MTWLEIVVLA LIQGLTEFLP ISSSAHLILP SEVWGWQDQG LAFDVAVHVG TLLAVMVYFR 70 80 90 100 110 120 ADIFNLLNGW IKQITGGGAS QESRLAWAVI LGTIPACVAG LLLDSWIEEN LRSALVIALT 130 140 150 160 170 180 TIGFGVLLGM ADRKEGTRDI DQFTLKDALI IGVSQALALI PGTSRSGITM TSALFLGLNR 190 200 210 220 230 240 DTAARFSFLL SIPLIAAAGL FKGLELADTG TSSQWSEIAG ATLISAVSAY ACIHLFLKFL 250 260 QKIGFMPFVI YRMLLGAGLL VWLYVA

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KCTC 2396.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000155 Genomic DNA. Translation: ABC28655.1.
RefSeq	YP_433080.1. NC_007645.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	349521.HCH_01816.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3839561.
KEGG	hch:HCH_01816.
PATRIC	22084562. VBIHahChe29232_1676.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	WMIALAT.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	HCHE349521:GHAL-1816-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_HAHCH

Accession

Primary (citable) accession number: Q2SL19

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program