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Q2SL19

- UPPP_HAHCH

UniProt

Q2SL19 - UPPP_HAHCH

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciHCHE349521:GHAL-1745-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:HCH_01816
    OrganismiHahella chejuensis (strain KCTC 2396)
    Taxonomic identifieri349521 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
    ProteomesiUP000000238: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatasePRO_0000250238Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349521.HCH_01816.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei111 – 13121HelicalUniRule annotationAdd
    BLAST
    Transmembranei143 – 16321HelicalUniRule annotationAdd
    BLAST
    Transmembranei186 – 20621HelicalUniRule annotationAdd
    BLAST
    Transmembranei217 – 23721HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiMENIGWK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2SL19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWLEIVVLA LIQGLTEFLP ISSSAHLILP SEVWGWQDQG LAFDVAVHVG    50
    TLLAVMVYFR ADIFNLLNGW IKQITGGGAS QESRLAWAVI LGTIPACVAG 100
    LLLDSWIEEN LRSALVIALT TIGFGVLLGM ADRKEGTRDI DQFTLKDALI 150
    IGVSQALALI PGTSRSGITM TSALFLGLNR DTAARFSFLL SIPLIAAAGL 200
    FKGLELADTG TSSQWSEIAG ATLISAVSAY ACIHLFLKFL QKIGFMPFVI 250
    YRMLLGAGLL VWLYVA 266
    Length:266
    Mass (Da):28,588
    Last modified:January 24, 2006 - v1
    Checksum:i5E3C68A792B53439
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000155 Genomic DNA. Translation: ABC28655.1.
    RefSeqiYP_433080.1. NC_007645.1.

    Genome annotation databases

    EnsemblBacteriaiABC28655; ABC28655; HCH_01816.
    GeneIDi3839561.
    KEGGihch:HCH_01816.
    PATRICi22084562. VBIHahChe29232_1676.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000155 Genomic DNA. Translation: ABC28655.1 .
    RefSeqi YP_433080.1. NC_007645.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349521.HCH_01816.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC28655 ; ABC28655 ; HCH_01816 .
    GeneIDi 3839561.
    KEGGi hch:HCH_01816.
    PATRICi 22084562. VBIHahChe29232_1676.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi MENIGWK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci HCHE349521:GHAL-1745-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KCTC 2396.

    Entry informationi

    Entry nameiUPPP_HAHCH
    AccessioniPrimary (citable) accession number: Q2SL19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3