ID   ASTD_HAHCH              Reviewed;         490 AA.
AC   Q2SKP1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=HCH_01950;
OS   Hahella chejuensis (strain KCTC 2396).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Hahellaceae; Hahella.
OX   NCBI_TaxID=349521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16352867; DOI=10.1093/nar/gki1016;
RA   Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H.,
RA   Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H.,
RA   Park H.-S., Lee H.K., Oh T.K., Kim J.F.;
RT   "Genomic blueprint of Hahella chejuensis, a marine microbe producing
RT   an algicidal agent.";
RL   Nucleic Acids Res. 33:7066-7073(2005).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000155; ABC28783.1; -; Genomic_DNA.
DR   RefSeq; YP_433208.1; -.
DR   GeneID; 3837865; -.
DR   GenomeReviews; CP000155_GR; HCH_01950.
DR   KEGG; hch:HCH_01950; -.
DR   NMPDR; fig|349521.5.peg.1755; -.
DR   HOGENOM; Q2SKP1; -.
DR   OMA; Q2SKP1; EMTQPQA.
DR   BioCyc; HCHE349521:HCH_01950-MON; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    490       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000262403.
FT   NP_BIND     224    229       NAD (By similarity).
FT   ACT_SITE    247    247       By similarity.
FT   ACT_SITE    281    281       By similarity.
SQ   SEQUENCE   490 AA;  52550 MW;  FDAD0B3A871A7E12 CRC64;
     MTVRESAFVN GRWLAGGGVE FESLDPVTQD CLWKGAAASD DVVGQAVQAA RQAFTSWGRL
     DVSRRIDIVK RFAELLEEDK ERLADVIGKE TSKPLWEART EVASMVAKVG ISIQAFNERT
     GVSEQDVAAG HAVLKHRPHG VLAVFGPYNF PGHLPNGHIV PALIAGNTIV FKPSELTPWF
     AEETVRIWAK AGLPDGVLNL VQGARETGVA LAANDGIDGL LFTGSSPTGH SLHRQFGGRP
     EKILALEMGG NNPLIIAPPY DLKGAVHHTL FSAFVSAGQR CTCARRLLVP DTAEGQAFLD
     ELIAAAANLQ VGRYDADPQP FMGGVISLRA RDQMLAAQNK LAAEGGRILL EMRSLEENAS
     LLSPGVIDVT DVQELPDEEH FGPMLQVLRY RDFDHALELA NKTGFGLAAG LISDSRDLYD
     RFWLEVRAGI VNWNKPLTGA SSAAPFGGVG ASGNHRPSAY YAADYCAYPV ATLEADQAQA
     PAQLSPGMSL
//