Reviewed, UniProtKB/Swiss-Prot Q2SKP1 (ASTD_HAHCH)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	HCH_01950

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_0000262403
Regions
	Nucleotide binding	224 – 229	6	NAD By similarity
Sites
	Active site	247	1	By similarity
	Active site	281	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SKP1-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: FDAD0B3A871A7E12	FASTA	490	52,550
	10 20 30 40 50 60 MTVRESAFVN GRWLAGGGVE FESLDPVTQD CLWKGAAASD DVVGQAVQAA RQAFTSWGRL 70 80 90 100 110 120 DVSRRIDIVK RFAELLEEDK ERLADVIGKE TSKPLWEART EVASMVAKVG ISIQAFNERT 130 140 150 160 170 180 GVSEQDVAAG HAVLKHRPHG VLAVFGPYNF PGHLPNGHIV PALIAGNTIV FKPSELTPWF 190 200 210 220 230 240 AEETVRIWAK AGLPDGVLNL VQGARETGVA LAANDGIDGL LFTGSSPTGH SLHRQFGGRP 250 260 270 280 290 300 EKILALEMGG NNPLIIAPPY DLKGAVHHTL FSAFVSAGQR CTCARRLLVP DTAEGQAFLD 310 320 330 340 350 360 ELIAAAANLQ VGRYDADPQP FMGGVISLRA RDQMLAAQNK LAAEGGRILL EMRSLEENAS 370 380 390 400 410 420 LLSPGVIDVT DVQELPDEEH FGPMLQVLRY RDFDHALELA NKTGFGLAAG LISDSRDLYD 430 440 450 460 470 480 RFWLEVRAGI VNWNKPLTGA SSAAPFGGVG ASGNHRPSAY YAADYCAYPV ATLEADQAQA 490 PAQLSPGMSL

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000155 Genomic DNA. Translation: ABC28783.1.
RefSeq	YP_433208.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3837865.
GenomeReviews	Gene locus HCH_01950 in contig CP000155_GR.
KEGG	hch:HCH_01950.
NMPDR	fig|349521.5.peg.1755.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2SKP1.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_01950-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_HAHCH

Accession

Primary (citable) accession number: Q2SKP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)