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Reviewed, UniProtKB/Swiss-Prot Q2SKP1 (ASTD_HAHCH)

Last modified March 2, 2010. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase

EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:HCH_01950
OrganismHahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]
Taxonomic identifier349521 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
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Protein attributesHide

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

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OntologiesHide

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...
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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_0000262403

Regions

Nucleotide binding224 – 2296NAD By similarity

Sites

Active site2471 By similarity
Active site2811 By similarity
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SequencesHide

Sequence LengthMass (Da)Tools
Q2SKP1-1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: FDAD0B3A871A7E12

FASTA49052,550
        10         20         30         40         50         60 
MTVRESAFVN GRWLAGGGVE FESLDPVTQD CLWKGAAASD DVVGQAVQAA RQAFTSWGRL 

        70         80         90        100        110        120 
DVSRRIDIVK RFAELLEEDK ERLADVIGKE TSKPLWEART EVASMVAKVG ISIQAFNERT 

       130        140        150        160        170        180 
GVSEQDVAAG HAVLKHRPHG VLAVFGPYNF PGHLPNGHIV PALIAGNTIV FKPSELTPWF 

       190        200        210        220        230        240 
AEETVRIWAK AGLPDGVLNL VQGARETGVA LAANDGIDGL LFTGSSPTGH SLHRQFGGRP 

       250        260        270        280        290        300 
EKILALEMGG NNPLIIAPPY DLKGAVHHTL FSAFVSAGQR CTCARRLLVP DTAEGQAFLD 

       310        320        330        340        350        360 
ELIAAAANLQ VGRYDADPQP FMGGVISLRA RDQMLAAQNK LAAEGGRILL EMRSLEENAS 

       370        380        390        400        410        420 
LLSPGVIDVT DVQELPDEEH FGPMLQVLRY RDFDHALELA NKTGFGLAAG LISDSRDLYD 

       430        440        450        460        470        480 
RFWLEVRAGI VNWNKPLTGA SSAAPFGGVG ASGNHRPSAY YAADYCAYPV ATLEADQAQA 

       490 
PAQLSPGMSL 

« Hide

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ReferencesHide

[1]"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent."
Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F.
Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
CP000155 Genomic DNA. Translation: ABC28783.1.
RefSeqYP_433208.1.

3D structure databases

SMRQ2SKP1. Positions 7-472.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2SKP1.

Genome annotation databases

GeneID3837865.
GenomeReviewsGene locus HCH_01950 in contig CP000155_GR.
KEGGhch:HCH_01950.
NMPDRfig|349521.5.peg.1755.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAEMTQPQA.
PhylomeDBQ2SKP1.

Enzyme and pathway databases

BioCycHCHE349521:HCH_01950-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...
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Entry informationHide

Entry nameASTD_HAHCH
AccessionPrimary (citable) accession number: Q2SKP1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 24, 2006
Last modified: March 2, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
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Relevant documentsHide

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents