Reviewed, UniProtKB/Swiss-Prot Q2SIP2 (STHA_HAHCH)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	HCH_02695

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD(+) = NADP(+) + NADH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Soluble pyridine nucleotide transhydrogenase		PRO_0000260236
Regions
	Nucleotide binding	35 – 44	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SIP2-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 1CEE8949202C5AD8	FASTA	464	51,435
	10 20 30 40 50 60 MAEYRYDVVV IGAGPAGEGA AMNAAKHGKR VAVIEDKSQV GGNCTHMGTI PSKALRHAVK 70 80 90 100 110 120 QIIQFNTNTM FRDIGEPRWF SFPRVLQNAE RVIGKQVKIR TQFYARNRVD LYRGRASFID 130 140 150 160 170 180 ENRIEVRGGL NGKEVLYGKQ IVIATGSRPY LPEDVDFTHR RIYNSDSILK LSHTPRTLII 190 200 210 220 230 240 YGAGVIGCEY ASIFVGLGVK VDLINPGERL LSFLDGEISD ALSYHLRDNG VLVRHNEQYD 250 260 270 280 290 300 SVVGDDHGVV LTMKSGKRIR ADAFLWCNGR TGNTDNLGLE NIGLEPNARG QLAVDNHYRT 310 320 330 340 350 360 KIPHVFAAGD VIGWPSLASA AYDQGRSASS EIVKDDFFRF ITDVPTGIYT IPEISSVGRT 370 380 390 400 410 420 EAELTEAKVP YEVGQAFFKD LARAQITGDT VGMLKLLFHR ETMELLGIHC FGDQASEIVH 430 440 450 460 IGQAIMNQPG ELNTIEYFVN TTFNYPTMAE AYRVAALNGL NRIF

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000155 Genomic DNA. Translation: ABC29482.1.
RefSeq	YP_433907.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3839006.
GenomeReviews	Gene locus HCH_02695 in contig CP000155_GR.
KEGG	hch:HCH_02695.
NMPDR	fig|349521.5.peg.2402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2SIP2.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_02695-MON.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR000759. Adrndx_reductase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR001100. Pyr_nuc-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00419. ADXRDTASE. PR00368. FADPNR. PR00945. HGRDTASE. PR00411. PNDRDTASEI.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_HAHCH

Accession

Primary (citable) accession number: Q2SIP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)