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Q2SIP2 (STHA_HAHCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1
Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]
Gene names
Name:sthA
Ordered Locus Names:HCH_02695
OrganismHahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]
Taxonomic identifier349521 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247

Catalytic activity

NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_00247

Subcellular location

Cytoplasm By similarity HAMAP MF_00247.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)+ transhydrogenase (B-specific) activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247
PRO_0000260236

Regions

Nucleotide binding35 – 4410FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2SIP2 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 1CEE8949202C5AD8

FASTA46451,435
        10         20         30         40         50         60 
MAEYRYDVVV IGAGPAGEGA AMNAAKHGKR VAVIEDKSQV GGNCTHMGTI PSKALRHAVK 

        70         80         90        100        110        120 
QIIQFNTNTM FRDIGEPRWF SFPRVLQNAE RVIGKQVKIR TQFYARNRVD LYRGRASFID 

       130        140        150        160        170        180 
ENRIEVRGGL NGKEVLYGKQ IVIATGSRPY LPEDVDFTHR RIYNSDSILK LSHTPRTLII 

       190        200        210        220        230        240 
YGAGVIGCEY ASIFVGLGVK VDLINPGERL LSFLDGEISD ALSYHLRDNG VLVRHNEQYD 

       250        260        270        280        290        300 
SVVGDDHGVV LTMKSGKRIR ADAFLWCNGR TGNTDNLGLE NIGLEPNARG QLAVDNHYRT 

       310        320        330        340        350        360 
KIPHVFAAGD VIGWPSLASA AYDQGRSASS EIVKDDFFRF ITDVPTGIYT IPEISSVGRT 

       370        380        390        400        410        420 
EAELTEAKVP YEVGQAFFKD LARAQITGDT VGMLKLLFHR ETMELLGIHC FGDQASEIVH 

       430        440        450        460 
IGQAIMNQPG ELNTIEYFVN TTFNYPTMAE AYRVAALNGL NRIF

« Hide

References

[1]"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent."
Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F.
Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KCTC 2396.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000155 Genomic DNA. Translation: ABC29482.1.
RefSeqYP_433907.1. NC_007645.1.

3D structure databases

HSSPHSSP built from PDB template 2F5Z based on UniProtKB P09622.
ProteinModelPortalQ2SIP2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2SIP2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3839006.
GenomeReviewsGene locus HCH_02695 in contig CP000155_GR.
KEGGhch:HCH_02695.
NMPDRfig|349521.5.peg.2402.
PATRIC22086188. VBIHahChe29232_2468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1249.
HOGENOMHBG515043.
OMARSTHFDA.
PhylomeDBQ2SIP2.
ProtClustDBPRK05249.

Enzyme and pathway databases

BioCycHCHE349521:HCH_02695-MONOMER.

Family and domain databases

HAMAPMF_00247. SthA.
[Tree]
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR022962. STH.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00322.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSTHA_HAHCH
AccessionPrimary (citable) accession number: Q2SIP2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 24, 2006
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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