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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:HCH_02703
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

Subcellular locationi

Q2SIN5:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalUniRule annotationAdd BLAST21
Transmembranei65 – 85HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 163HelicalUniRule annotationAdd BLAST21
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716311 – 585Lipid A export ATP-binding/permease protein MsbAAdd BLAST585

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi349521.HCH_02703.

Structurei

3D structure databases

ProteinModelPortaliQ2SIN5.
SMRiQ2SIN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 310ABC transmembrane type-1UniRule annotationAdd BLAST283
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SIN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVAKQYAG AQVYGRLLSY LKPLWKVFAL AVLGNVIYAL ASAAMADATK
60 70 80 90 100
YIVAAIETPS PEGRLLVPML IIGIFALRGL GSFCGGYFMA RVARGIVHRM
110 120 130 140 150
RLELFRHLTV LPCRFFDSNS TGHLVSRITY NVDQVTGAAT NAITVVLREG
160 170 180 190 200
FTVIGLMGYM IYVSWKLTLL FLVLGPIIGV LIGYVSKRFR RISRRIQSSM
210 220 230 240 250
GDVTHVASES IGGYRVMRTF GGEEYEFNRF MKASEYNITQ ALKMSLTQAL
260 270 280 290 300
STPIIQLVIS VFIALLVWLA LSPEVRGNMS TGEFLAYITA ATTCAKPIRQ
310 320 330 340 350
LTEVNAVIQR GISAAQDVFM QLDEPVEKDE GSYVADRVQG RLEFKSLGFA
360 370 380 390 400
YSDEGKPALQ EINLVIEPGE TVALVGRSGS GKSTLVNLLP RFYDYEQGEI
410 420 430 440 450
LLDGKPLKDF ALTSLRRQIS IVTQQVVLFN DTVTNNIAYG ALADATPEQV
460 470 480 490 500
REAAKSADAL GFIEQLEQGF DTLLGENGTR LSGGQRQRMV IARALLKDSP
510 520 530 540 550
ILILDEATSA LDTHAERNIQ SALETLMKGR TTLVVAHRLS TIENADKIVV
560 570 580
MDQGRIVEVG SHRELIEKDG AYAALHKLQF SEADA
Length:585
Mass (Da):64,225
Last modified:January 24, 2006 - v1
Checksum:iB12A65C88249F4B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC29489.1.
RefSeqiWP_011396558.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC29489; ABC29489; HCH_02703.
KEGGihch:HCH_02703.

Similar proteinsi

Entry informationi

Entry nameiMSBA_HAHCH
AccessioniPrimary (citable) accession number: Q2SIN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 24, 2006
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families