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Protein

Catalase-peroxidase

Gene

katG

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei87 – 871Transition state stabilizerUniRule annotation
Active sitei91 – 911Proton acceptorUniRule annotation
Metal bindingi254 – 2541Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciHCHE349521:GHAL-3080-MONOMER.

Protein family/group databases

PeroxiBasei2671. HchCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:HCH_03207
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Catalase-peroxidasePRO_0000354806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki90 ↔ 213Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-239)UniRule annotation
Cross-linki213 ↔ 239Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-90)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349521.HCH_03207.

Structurei

3D structure databases

ProteinModelPortaliQ2SHA6.
SMRiQ2SHA6. Positions 15-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiNPMGGDF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SHA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSKCPFHH APAEGTSNRD WWPNQLRLEI LHQRSALSNP LGEEFNYAEA
60 70 80 90 100
FKSLDLAAIK QDLTALMTDS QDWWPADFGH YGPLFIRMAW HSAGTYRTGD
110 120 130 140 150
GRGGGGTGNQ RFAPLNSWPD NVNLDKARRL LWPIKQKYGQ KISWADLMIL
160 170 180 190 200
AGNVALESMG FKTFGFGGGR ADIWEPEQDI YWGAEKTWLD DNRYSGDRDL
210 220 230 240 250
ENPLAAVQMG LIYVNPEGPN GNPDPVAAAK DIRETFARMA MDDEETVALI
260 270 280 290 300
AGGHTFGKTH GAGDAANVGP EPEAAGLEEQ GLGWRSSYGS GKAGDAITSG
310 320 330 340 350
LEVTWTETPT QWSNNFFENL FGYEWELTKS PAGAHQWVPK GGAGADKIPD
360 370 380 390 400
AHDPSKRHVP TMLTTDLSLR FDPAYEKISR RFYENPDQLA DAFARAWFKL
410 420 430 440 450
THRDMGPRAR YLGPEVPAEE LIWQDPIPAV DHPLINDQDI SALKSKILTS
460 470 480 490 500
GLSVAQMVST AWASASTFRG SDMRGGANGA RIRLAPQNEW EVNQPDQLAQ
510 520 530 540 550
VLKTLEGVQA EFNSAQSDGK KVSLADIIVL AGCAGVEKAA QNAGHTIKVP
560 570 580 590 600
FSPGRMDASQ EQTDIEAFEV LEPIADGFRN YMKGKYAVSP EELLVDRAQL
610 620 630 640 650
LTLTAPEMTV LIGGMRVLNA NVGQSKHGVF TQRPESLTND FFVNLLDMGT
660 670 680 690 700
VWKATSKEED LFEGRDRVTG DLKWTGTRID LVFGSNSQLR ALAEVYASSD
710 720
AQERFLKDFV AAWTKVMNLD RFDLA
Length:725
Mass (Da):79,920
Last modified:January 24, 2006 - v1
Checksum:i87FF955763C3D7E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC29968.1.
RefSeqiWP_011397037.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC29968; ABC29968; HCH_03207.
KEGGihch:HCH_03207.
PATRICi22087118. VBIHahChe29232_2932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC29968.1.
RefSeqiWP_011397037.1. NC_007645.1.

3D structure databases

ProteinModelPortaliQ2SHA6.
SMRiQ2SHA6. Positions 15-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349521.HCH_03207.

Protein family/group databases

PeroxiBasei2671. HchCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC29968; ABC29968; HCH_03207.
KEGGihch:HCH_03207.
PATRICi22087118. VBIHahChe29232_2932.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiNPMGGDF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciHCHE349521:GHAL-3080-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KCTC 2396.

Entry informationi

Entry nameiKATG_HAHCH
AccessioniPrimary (citable) accession number: Q2SHA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 24, 2006
Last modified: December 9, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.