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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181UniRule annotation1
Active sitei207UniRule annotation1
Active sitei303UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:HCH_03703
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642821 – 368Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi349521.HCH_03703.

Structurei

3D structure databases

ProteinModelPortaliQ2SFY4.
SMRiQ2SFY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini169 – 361CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiHAMAQTT.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SFY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAKIKVLLV DDSAVVRQVL QQVLERDKNI EVIGAAADPI FAQLRMSKQW
60 70 80 90 100
PDVIVLDVEM PRMDGITFLK KLMAERPTPV VMCSTLTSKG AQTSMKALAA
110 120 130 140 150
GAVAVVAKPA VGVKEYLESA AGELIMEIKA AAKANMRNMP AATASAQSMA
160 170 180 190 200
LPAKFSADAV IPLRTGGVIA GANKIAALGT STGGTQALEY VLTRLPRNCP
210 220 230 240 250
GIVIVQHMPE KFTAAFAERL NSICELEILE AESGHQVAPG RALIAPGGKH
260 270 280 290 300
MLLRRSGAQY FVEIMSGPPV NRHRPSVDVL FRSVAQAAGR NALGVIMTGM
310 320 330 340 350
GDDGAKGLLE MRNAGALTIG QDERSCIVYG MPKEAAKIGA VTREISLERI
360
PQCVLDMGAS LTASAQRG
Length:368
Mass (Da):38,865
Last modified:January 24, 2006 - v1
Checksum:i3391E8B49206B93B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC30440.1.
RefSeqiWP_011397508.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC30440; ABC30440; HCH_03703.
KEGGihch:HCH_03703.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_HAHCH
AccessioniPrimary (citable) accession number: Q2SFY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome