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Q2SFI6

- GCSP_HAHCH

UniProt

Q2SFI6 - GCSP_HAHCH

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciHCHE349521:GHAL-3700-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:HCH_03861
    OrganismiHahella chejuensis (strain KCTC 2396)
    Taxonomic identifieri349521 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
    ProteomesiUP000000238: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 960960Glycine dehydrogenase (decarboxylating)PRO_1000083208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi349521.HCH_03861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2SFI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiHRYRTET.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2SFI6-1 [UniParc]FASTAAdd to Basket

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    MSDTRETLAE LEQRDAFIGR HIGPDEAEKT AMLNALGVAD METLISKTVP    50
    ETIRIKEGLE LDGPCTEAQA LAELKAFAER NKVFKTYIGM GYYNTLTPTV 100
    ILRNVLENPA WYTAYTPYQP EISQGRLEAL LNFQTMIGDL TGMEMANASL 150
    LDEGTAAAEA MTMCRRVNGK NKSNVFFVAE DCLPQTIEVV KGRAEPLGIE 200
    VVVGDPQKDL QNHDYFAVLL QYPGVNGDVR DYRELIKTAH ESNALAIMAA 250
    DILSLTLLTP PGELGADIAI GNSQRFGVPL FFGGPHAAYI ATKDEYKRSL 300
    PGRLVGVSVD ANGDKAYRLA LQTREQHIRR QNATSNICTA QALLAITASM 350
    YGAYHGPEGL KRIARRVHRL TTILAEGLKQ AGRSVNTAHF FDTVSVATGG 400
    DTDAVYQAAL QQKINLRRID DNTLGVSLDE TTTREDVAAL LHVFASGKPV 450
    ADVATLDSSA KDAIPAELRR QSAFMTHTVF NRYHSETEML RYLRRLSDKD 500
    LALDRTMIPL GSCTMKLNAT TEMTPVSWDG FCAIHPFAPL DQTEGYRALI 550
    ADLERMLSAA TGYAAFSLQP NAGSQGEYAG LLAIRAYHHS RGEGDRDVCL 600
    IPNSAHGTNP ASAQMVGMKV VAVKCDDNGN VDLNDLRLKA EQHSAKLAAL 650
    MATYPSTHGV FEEGIREVCS IVHQHGGQVY IDGANLNAMV GLCKPGQFGG 700
    DVSHLNLHKT FCIPHGGGGP GVGPIGVAAH LAPFLPGHSA MGETADKAIA 750
    PISAAPWGSA GILPISWTYI RMMGGEGLTE ATKSAILNAN YIAKRLEPHY 800
    PVLYTGSQGF VAHECIIDVR PFKDSCGVTV DDIAKRLIDF GFHAPTMSFP 850
    VPGTLMIEPT ESESLAELDR FCDAMIAIRE EIRAIENGEY DVDHSPLHHA 900
    PHTAADLVGD WDRPYSRERG VYPLKALKAD KYWSPVGRID NVYGDRNLVC 950
    ACPPMTEYED 960
    Length:960
    Mass (Da):104,373
    Last modified:January 24, 2006 - v1
    Checksum:iE6D614BD4A1102B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000155 Genomic DNA. Translation: ABC30588.1.
    RefSeqiYP_435013.1. NC_007645.1.

    Genome annotation databases

    EnsemblBacteriaiABC30588; ABC30588; HCH_03861.
    GeneIDi3838964.
    KEGGihch:HCH_03861.
    PATRICi22088256. VBIHahChe29232_3501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000155 Genomic DNA. Translation: ABC30588.1 .
    RefSeqi YP_435013.1. NC_007645.1.

    3D structure databases

    ProteinModelPortali Q2SFI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349521.HCH_03861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC30588 ; ABC30588 ; HCH_03861 .
    GeneIDi 3838964.
    KEGGi hch:HCH_03861.
    PATRICi 22088256. VBIHahChe29232_3501.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi HRYRTET.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci HCHE349521:GHAL-3700-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KCTC 2396.

    Entry informationi

    Entry nameiGCSP_HAHCH
    AccessioniPrimary (citable) accession number: Q2SFI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3