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Q2SFI6

- GCSP_HAHCH

UniProt

Q2SFI6 - GCSP_HAHCH

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, HCH_03861
Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHCHE349521:GHAL-3700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:HCH_03861
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
ProteomesiUP000000238: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000083208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi349521.HCH_03861.

Structurei

3D structure databases

ProteinModelPortaliQ2SFI6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SFI6-1 [UniParc]FASTAAdd to Basket

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MSDTRETLAE LEQRDAFIGR HIGPDEAEKT AMLNALGVAD METLISKTVP    50
ETIRIKEGLE LDGPCTEAQA LAELKAFAER NKVFKTYIGM GYYNTLTPTV 100
ILRNVLENPA WYTAYTPYQP EISQGRLEAL LNFQTMIGDL TGMEMANASL 150
LDEGTAAAEA MTMCRRVNGK NKSNVFFVAE DCLPQTIEVV KGRAEPLGIE 200
VVVGDPQKDL QNHDYFAVLL QYPGVNGDVR DYRELIKTAH ESNALAIMAA 250
DILSLTLLTP PGELGADIAI GNSQRFGVPL FFGGPHAAYI ATKDEYKRSL 300
PGRLVGVSVD ANGDKAYRLA LQTREQHIRR QNATSNICTA QALLAITASM 350
YGAYHGPEGL KRIARRVHRL TTILAEGLKQ AGRSVNTAHF FDTVSVATGG 400
DTDAVYQAAL QQKINLRRID DNTLGVSLDE TTTREDVAAL LHVFASGKPV 450
ADVATLDSSA KDAIPAELRR QSAFMTHTVF NRYHSETEML RYLRRLSDKD 500
LALDRTMIPL GSCTMKLNAT TEMTPVSWDG FCAIHPFAPL DQTEGYRALI 550
ADLERMLSAA TGYAAFSLQP NAGSQGEYAG LLAIRAYHHS RGEGDRDVCL 600
IPNSAHGTNP ASAQMVGMKV VAVKCDDNGN VDLNDLRLKA EQHSAKLAAL 650
MATYPSTHGV FEEGIREVCS IVHQHGGQVY IDGANLNAMV GLCKPGQFGG 700
DVSHLNLHKT FCIPHGGGGP GVGPIGVAAH LAPFLPGHSA MGETADKAIA 750
PISAAPWGSA GILPISWTYI RMMGGEGLTE ATKSAILNAN YIAKRLEPHY 800
PVLYTGSQGF VAHECIIDVR PFKDSCGVTV DDIAKRLIDF GFHAPTMSFP 850
VPGTLMIEPT ESESLAELDR FCDAMIAIRE EIRAIENGEY DVDHSPLHHA 900
PHTAADLVGD WDRPYSRERG VYPLKALKAD KYWSPVGRID NVYGDRNLVC 950
ACPPMTEYED 960
Length:960
Mass (Da):104,373
Last modified:January 24, 2006 - v1
Checksum:iE6D614BD4A1102B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000155 Genomic DNA. Translation: ABC30588.1.
RefSeqiYP_435013.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC30588; ABC30588; HCH_03861.
GeneIDi3838964.
KEGGihch:HCH_03861.
PATRICi22088256. VBIHahChe29232_3501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000155 Genomic DNA. Translation: ABC30588.1 .
RefSeqi YP_435013.1. NC_007645.1.

3D structure databases

ProteinModelPortali Q2SFI6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349521.HCH_03861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC30588 ; ABC30588 ; HCH_03861 .
GeneIDi 3838964.
KEGGi hch:HCH_03861.
PATRICi 22088256. VBIHahChe29232_3501.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci HCHE349521:GHAL-3700-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KCTC 2396.

Entry informationi

Entry nameiGCSP_HAHCH
AccessioniPrimary (citable) accession number: Q2SFI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi