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Q2SFI6

- GCSP_HAHCH

UniProt

Q2SFI6 - GCSP_HAHCH

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHCHE349521:GHAL-3700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:HCH_03861
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
ProteomesiUP000000238: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Glycine dehydrogenase (decarboxylating)PRO_1000083208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi349521.HCH_03861.

Structurei

3D structure databases

ProteinModelPortaliQ2SFI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2SFI6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTRETLAE LEQRDAFIGR HIGPDEAEKT AMLNALGVAD METLISKTVP
60 70 80 90 100
ETIRIKEGLE LDGPCTEAQA LAELKAFAER NKVFKTYIGM GYYNTLTPTV
110 120 130 140 150
ILRNVLENPA WYTAYTPYQP EISQGRLEAL LNFQTMIGDL TGMEMANASL
160 170 180 190 200
LDEGTAAAEA MTMCRRVNGK NKSNVFFVAE DCLPQTIEVV KGRAEPLGIE
210 220 230 240 250
VVVGDPQKDL QNHDYFAVLL QYPGVNGDVR DYRELIKTAH ESNALAIMAA
260 270 280 290 300
DILSLTLLTP PGELGADIAI GNSQRFGVPL FFGGPHAAYI ATKDEYKRSL
310 320 330 340 350
PGRLVGVSVD ANGDKAYRLA LQTREQHIRR QNATSNICTA QALLAITASM
360 370 380 390 400
YGAYHGPEGL KRIARRVHRL TTILAEGLKQ AGRSVNTAHF FDTVSVATGG
410 420 430 440 450
DTDAVYQAAL QQKINLRRID DNTLGVSLDE TTTREDVAAL LHVFASGKPV
460 470 480 490 500
ADVATLDSSA KDAIPAELRR QSAFMTHTVF NRYHSETEML RYLRRLSDKD
510 520 530 540 550
LALDRTMIPL GSCTMKLNAT TEMTPVSWDG FCAIHPFAPL DQTEGYRALI
560 570 580 590 600
ADLERMLSAA TGYAAFSLQP NAGSQGEYAG LLAIRAYHHS RGEGDRDVCL
610 620 630 640 650
IPNSAHGTNP ASAQMVGMKV VAVKCDDNGN VDLNDLRLKA EQHSAKLAAL
660 670 680 690 700
MATYPSTHGV FEEGIREVCS IVHQHGGQVY IDGANLNAMV GLCKPGQFGG
710 720 730 740 750
DVSHLNLHKT FCIPHGGGGP GVGPIGVAAH LAPFLPGHSA MGETADKAIA
760 770 780 790 800
PISAAPWGSA GILPISWTYI RMMGGEGLTE ATKSAILNAN YIAKRLEPHY
810 820 830 840 850
PVLYTGSQGF VAHECIIDVR PFKDSCGVTV DDIAKRLIDF GFHAPTMSFP
860 870 880 890 900
VPGTLMIEPT ESESLAELDR FCDAMIAIRE EIRAIENGEY DVDHSPLHHA
910 920 930 940 950
PHTAADLVGD WDRPYSRERG VYPLKALKAD KYWSPVGRID NVYGDRNLVC
960
ACPPMTEYED
Length:960
Mass (Da):104,373
Last modified:January 24, 2006 - v1
Checksum:iE6D614BD4A1102B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000155 Genomic DNA. Translation: ABC30588.1.
RefSeqiYP_435013.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC30588; ABC30588; HCH_03861.
GeneIDi3838964.
KEGGihch:HCH_03861.
PATRICi22088256. VBIHahChe29232_3501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000155 Genomic DNA. Translation: ABC30588.1 .
RefSeqi YP_435013.1. NC_007645.1.

3D structure databases

ProteinModelPortali Q2SFI6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349521.HCH_03861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC30588 ; ABC30588 ; HCH_03861 .
GeneIDi 3838964.
KEGGi hch:HCH_03861.
PATRICi 22088256. VBIHahChe29232_3501.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci HCHE349521:GHAL-3700-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KCTC 2396.

Entry informationi

Entry nameiGCSP_HAHCH
AccessioniPrimary (citable) accession number: Q2SFI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3