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Q2SFI6 (GCSP_HAHCH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:HCH_03861
OrganismHahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]
Taxonomic identifier349521 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella

Protein attributes

Sequence length960 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 960960Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083208

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2SFI6 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: E6D614BD4A1102B8

FASTA960104,373
        10         20         30         40         50         60 
MSDTRETLAE LEQRDAFIGR HIGPDEAEKT AMLNALGVAD METLISKTVP ETIRIKEGLE 

        70         80         90        100        110        120 
LDGPCTEAQA LAELKAFAER NKVFKTYIGM GYYNTLTPTV ILRNVLENPA WYTAYTPYQP 

       130        140        150        160        170        180 
EISQGRLEAL LNFQTMIGDL TGMEMANASL LDEGTAAAEA MTMCRRVNGK NKSNVFFVAE 

       190        200        210        220        230        240 
DCLPQTIEVV KGRAEPLGIE VVVGDPQKDL QNHDYFAVLL QYPGVNGDVR DYRELIKTAH 

       250        260        270        280        290        300 
ESNALAIMAA DILSLTLLTP PGELGADIAI GNSQRFGVPL FFGGPHAAYI ATKDEYKRSL 

       310        320        330        340        350        360 
PGRLVGVSVD ANGDKAYRLA LQTREQHIRR QNATSNICTA QALLAITASM YGAYHGPEGL 

       370        380        390        400        410        420 
KRIARRVHRL TTILAEGLKQ AGRSVNTAHF FDTVSVATGG DTDAVYQAAL QQKINLRRID 

       430        440        450        460        470        480 
DNTLGVSLDE TTTREDVAAL LHVFASGKPV ADVATLDSSA KDAIPAELRR QSAFMTHTVF 

       490        500        510        520        530        540 
NRYHSETEML RYLRRLSDKD LALDRTMIPL GSCTMKLNAT TEMTPVSWDG FCAIHPFAPL 

       550        560        570        580        590        600 
DQTEGYRALI ADLERMLSAA TGYAAFSLQP NAGSQGEYAG LLAIRAYHHS RGEGDRDVCL 

       610        620        630        640        650        660 
IPNSAHGTNP ASAQMVGMKV VAVKCDDNGN VDLNDLRLKA EQHSAKLAAL MATYPSTHGV 

       670        680        690        700        710        720 
FEEGIREVCS IVHQHGGQVY IDGANLNAMV GLCKPGQFGG DVSHLNLHKT FCIPHGGGGP 

       730        740        750        760        770        780 
GVGPIGVAAH LAPFLPGHSA MGETADKAIA PISAAPWGSA GILPISWTYI RMMGGEGLTE 

       790        800        810        820        830        840 
ATKSAILNAN YIAKRLEPHY PVLYTGSQGF VAHECIIDVR PFKDSCGVTV DDIAKRLIDF 

       850        860        870        880        890        900 
GFHAPTMSFP VPGTLMIEPT ESESLAELDR FCDAMIAIRE EIRAIENGEY DVDHSPLHHA 

       910        920        930        940        950        960 
PHTAADLVGD WDRPYSRERG VYPLKALKAD KYWSPVGRID NVYGDRNLVC ACPPMTEYED 

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References

[1]"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent."
Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F.
Nucleic Acids Res. 33:7066-7073(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KCTC 2396.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000155 Genomic DNA. Translation: ABC30588.1.
RefSeqYP_435013.1. NC_007645.1.

3D structure databases

ProteinModelPortalQ2SFI6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349521.HCH_03861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC30588; ABC30588; HCH_03861.
GeneID3838964.
KEGGhch:HCH_03861.
PATRIC22088256. VBIHahChe29232_3501.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAHRYRTET.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycHCHE349521:GHAL-3700-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_HAHCH
AccessionPrimary (citable) accession number: Q2SFI6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families