Reviewed, UniProtKB/Swiss-Prot Q2SEP8 (HUTI_HAHCH)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	HCH_04169

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	Imidazolonepropionase HAMAP MF_00372		PRO_0000306465
Sites
	Metal binding	68	1	Zinc or iron By similarity
	Metal binding	70	1	Zinc or iron By similarity
	Metal binding	238	1	Zinc or iron By similarity
	Metal binding	313	1	Zinc or iron By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	90	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	173	1	Substrate By similarity
	Binding site	241	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2SEP8-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 17A95162680EAD0B	FASTA	403	43,948
	10 20 30 40 50 60 MDWWINARIA TLDPDAQHAY GLLESHALGV AHGKVEAIVP MSEWDGDASD NITDANGRLI 70 80 90 100 110 120 TPGLVDCHTH LVYGGDRAAE FEMRLQGVSY ADIAKQGGGI ISTVRATRAA TEKELLQQSE 130 140 150 160 170 180 KRLLALLREG VTTVEIKSGY GLDLESELKM LHVARRLGQR YPVNVRTTLL AAHALPPEYA 190 200 210 220 230 240 GRSDDYISWI CEEALPVAHE QKLADAVDVF CESIAFTPEQ CRRVFEAAQK LGLPVKGHME 250 260 270 280 290 300 QLTLSGGSAL AAEFNALSVD HVEYLDEASV QAIAASGTVA TLLPGAFYFL RETQRPPMEL 310 320 330 340 350 360 LRKHKVPMAL ATDLNPGSCP LASMRLMMNM GCTFFGMTPE ETLAGVTRHG AKALGMQDRI 370 380 390 400 GHLAPGMAAD FIVWDCQHPA QLSYEFGVTG PHQRVFHGEI HNV

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000155 Genomic DNA. Translation: ABC30876.1.
RefSeq	YP_435301.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3841617.
GenomeReviews	Gene locus HCH_04169 in contig CP000155_GR.
KEGG	hch:HCH_04169.
NMPDR	fig|349521.5.peg.3643.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2SEP8.
OMA	Q2SEP8. MNMACTL.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_04169-MON.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 2 hits. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_HAHCH

Accession

Primary (citable) accession number: Q2SEP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)