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Reviewed, UniProtKB/Swiss-Prot Q2SDQ1 (URE1_HAHCH)

Last modified November 3, 2009. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Urease subunit alpha
    EC=3.5.1.5
Alternative name(s):
    Urea amidohydrolase subunit alpha
Gene names
Name: ureC
Ordered Locus Names: HCH_04523
OrganismHahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]
Taxonomic identifier349521 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

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Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Urea + H2O = CO2 + 2 NH3. HAMAP MF_01953

Cofactor

Binds 2 nickel ions per subunit By similarity.

Pathway

Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_01953

Subunit structure

Heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Carbamylation allows a single lysine to coordinate two nickel ions By similarity.

Sequence similarities

Belongs to the urease family.

Contains 1 urease domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Nickel
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processurea metabolic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnickel ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

urease activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Urease subunit alpha HAMAP MF_01953
PRO_0000239876

Regions

Domain129 – 567439Urease

Sites

Active site3201Proton donor By similarity
Metal binding1341Nickel 2 By similarity
Metal binding1361Nickel 2 By similarity
Metal binding2171Nickel 1; via carbamate group By similarity
Metal binding2171Nickel 2; via carbamate group By similarity
Metal binding2461Nickel 1 By similarity
Metal binding2721Nickel 1 By similarity
Metal binding3601Nickel 2 By similarity
Binding site2191Substrate By similarity

Amino acid modifications

Modified residue2171N6-carboxylysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2SDQ1-1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 0D86AF30D6C051E6

FASTA56760,924
        10         20         30         40         50         60 
MAKISRAAYA DMFGPTVGDR VRLGDTELWI EVEKDYATYG HEVKFGGGKV IRDGMGQSQR 

        70         80         90        100        110        120 
PNTEAVDTVI TNALILDHWG VVKADIGLKQ GRIAAIGKAG NPDIQDNIDI IIGPGTEVIA 

       130        140        150        160        170        180 
GEGMIATAGG IDAHIHFICP QQIEEALMSG VTTMLGGGAG PATGTNATTC TPGPWHMGKM 

       190        200        210        220        230        240 
LQAADAFPMN LGFLGKGNAS LPAALEEQML AGAMGLKLHE DWGTTPASID NCLNIAEKYD 

       250        260        270        280        290        300 
VQVAIHTDTL NESGFVEDTL AAFKGRTIHT YHTEGAGGGH APDIIKACGE LNVLPSSTNP 

       310        320        330        340        350        360 
TRPYTINTVD EHLDMLMVCH HLDPDIPEDV AFADSRIRKE TIAAEDILHD LGAFSMISSD 

       370        380        390        400        410        420 
SQAMGRVGEV VCRTWQTAHK MKVQRGPLAQ DSERADNFRA KRYIAKYTIN PAIAHGIAHE 

       430        440        450        460        470        480 
VGSLEPGKLA DIILWRPAFF GAKPSLIIKG GMIAAAPMGD ANASIPTPQP VHYRPMFGAF 

       490        500        510        520        530        540 
GRAMQQTRLT FVCQAALDNG VKEQFGLQSP LSACRNTRTV TKKSMVLNDL TPQMEVDSQT 

       550        560 
YEVRANGELL VCEPAKVLPL AQRYFLF

« Hide

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References

[1]"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent."
Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F.
Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000155 Genomic DNA. Translation: ABC31223.1.
RefSeqYP_435648.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2SDQ1.

Genome annotation databases

GeneID3843355.
GenomeReviewsGene locus HCH_04523 in contig CP000155_GR.
KEGGhch:HCH_04523.
NMPDRfig|349521.5.peg.3959.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2SDQ1.
OMASHIHFIC.

Enzyme and pathway databases

BioCycHCHE349521:HCH_04523-MON.

Family and domain databases

HAMAPMF_01953.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR011612. Urease_alpha_N.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR017952. Urease_asu_core.
IPR017950. Urease_asu_CS.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSPR01752. UREASE.
TIGRFAMsTIGR01792. urease_alph. 1 hit.
PROSITEPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameURE1_HAHCH
AccessionPrimary (citable) accession number: Q2SDQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 24, 2006
Last modified: November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents