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Protein

Urease subunit alpha

Gene

ureC

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi136Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi217Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi217Nickel 2; via carbamate groupUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Metal bindingi246Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi272Nickel 2; via tele nitrogenUniRule annotation1
Active sitei320Proton donorUniRule annotation1
Metal bindingi360Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nickel

Enzyme and pathway databases

BioCyciHCHE349521:G1G5E-4057-MONOMER
UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:HCH_04523
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398761 – 567Urease subunit alphaAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Proteomic databases

PRIDEiQ2SDQ1

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi349521.HCH_04523

Structurei

3D structure databases

ProteinModelPortaliQ2SDQ1
SMRiQ2SDQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 567UreaseUniRule annotationAdd BLAST439

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM Bacteria
COG0804 LUCA
HOGENOMiHOG000075064
KOiK01428
OMAiGFDSHIH
OrthoDBiPOG091H0ARR

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2SDQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKISRAAYA DMFGPTVGDR VRLGDTELWI EVEKDYATYG HEVKFGGGKV
60 70 80 90 100
IRDGMGQSQR PNTEAVDTVI TNALILDHWG VVKADIGLKQ GRIAAIGKAG
110 120 130 140 150
NPDIQDNIDI IIGPGTEVIA GEGMIATAGG IDAHIHFICP QQIEEALMSG
160 170 180 190 200
VTTMLGGGAG PATGTNATTC TPGPWHMGKM LQAADAFPMN LGFLGKGNAS
210 220 230 240 250
LPAALEEQML AGAMGLKLHE DWGTTPASID NCLNIAEKYD VQVAIHTDTL
260 270 280 290 300
NESGFVEDTL AAFKGRTIHT YHTEGAGGGH APDIIKACGE LNVLPSSTNP
310 320 330 340 350
TRPYTINTVD EHLDMLMVCH HLDPDIPEDV AFADSRIRKE TIAAEDILHD
360 370 380 390 400
LGAFSMISSD SQAMGRVGEV VCRTWQTAHK MKVQRGPLAQ DSERADNFRA
410 420 430 440 450
KRYIAKYTIN PAIAHGIAHE VGSLEPGKLA DIILWRPAFF GAKPSLIIKG
460 470 480 490 500
GMIAAAPMGD ANASIPTPQP VHYRPMFGAF GRAMQQTRLT FVCQAALDNG
510 520 530 540 550
VKEQFGLQSP LSACRNTRTV TKKSMVLNDL TPQMEVDSQT YEVRANGELL
560
VCEPAKVLPL AQRYFLF
Length:567
Mass (Da):60,924
Last modified:January 24, 2006 - v1
Checksum:i0D86AF30D6C051E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA Translation: ABC31223.1
RefSeqiWP_011398290.1, NC_007645.1

Genome annotation databases

EnsemblBacteriaiABC31223; ABC31223; HCH_04523
KEGGihch:HCH_04523

Similar proteinsi

Entry informationi

Entry nameiURE1_HAHCH
AccessioniPrimary (citable) accession number: Q2SDQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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