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Protein

Urease subunit alpha

Gene

ureC

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi136 – 1361Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi217 – 2171Nickel 1; via carbamate groupUniRule annotation
Metal bindingi217 – 2171Nickel 2; via carbamate groupUniRule annotation
Binding sitei219 – 2191SubstrateUniRule annotation
Metal bindingi246 – 2461Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi272 – 2721Nickel 2; via tele nitrogenUniRule annotation
Active sitei320 – 3201Proton donorUniRule annotation
Metal bindingi360 – 3601Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciHCHE349521:GHAL-4338-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:HCH_04523
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Urease subunit alphaPRO_0000239876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi349521.HCH_04523.

Structurei

3D structure databases

ProteinModelPortaliQ2SDQ1.
SMRiQ2SDQ1. Positions 2-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 567439UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiEOG6ND0GM.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SDQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKISRAAYA DMFGPTVGDR VRLGDTELWI EVEKDYATYG HEVKFGGGKV
60 70 80 90 100
IRDGMGQSQR PNTEAVDTVI TNALILDHWG VVKADIGLKQ GRIAAIGKAG
110 120 130 140 150
NPDIQDNIDI IIGPGTEVIA GEGMIATAGG IDAHIHFICP QQIEEALMSG
160 170 180 190 200
VTTMLGGGAG PATGTNATTC TPGPWHMGKM LQAADAFPMN LGFLGKGNAS
210 220 230 240 250
LPAALEEQML AGAMGLKLHE DWGTTPASID NCLNIAEKYD VQVAIHTDTL
260 270 280 290 300
NESGFVEDTL AAFKGRTIHT YHTEGAGGGH APDIIKACGE LNVLPSSTNP
310 320 330 340 350
TRPYTINTVD EHLDMLMVCH HLDPDIPEDV AFADSRIRKE TIAAEDILHD
360 370 380 390 400
LGAFSMISSD SQAMGRVGEV VCRTWQTAHK MKVQRGPLAQ DSERADNFRA
410 420 430 440 450
KRYIAKYTIN PAIAHGIAHE VGSLEPGKLA DIILWRPAFF GAKPSLIIKG
460 470 480 490 500
GMIAAAPMGD ANASIPTPQP VHYRPMFGAF GRAMQQTRLT FVCQAALDNG
510 520 530 540 550
VKEQFGLQSP LSACRNTRTV TKKSMVLNDL TPQMEVDSQT YEVRANGELL
560
VCEPAKVLPL AQRYFLF
Length:567
Mass (Da):60,924
Last modified:January 24, 2006 - v1
Checksum:i0D86AF30D6C051E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC31223.1.
RefSeqiWP_011398290.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC31223; ABC31223; HCH_04523.
KEGGihch:HCH_04523.
PATRICi22089472. VBIHahChe29232_4106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC31223.1.
RefSeqiWP_011398290.1. NC_007645.1.

3D structure databases

ProteinModelPortaliQ2SDQ1.
SMRiQ2SDQ1. Positions 2-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349521.HCH_04523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC31223; ABC31223; HCH_04523.
KEGGihch:HCH_04523.
PATRICi22089472. VBIHahChe29232_4106.

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiEOG6ND0GM.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.
BioCyciHCHE349521:GHAL-4338-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KCTC 2396.

Entry informationi

Entry nameiURE1_HAHCH
AccessioniPrimary (citable) accession number: Q2SDQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 24, 2006
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.