Dihydroorotase - Hahella chejuensis (strain KCTC 2396)

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Reviewed, UniProtKB/Swiss-Prot Q2SCE3 (PYRC_HAHCH)

Last modified November 25, 2008. Version 21. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3

Gene names

Name:	pyrC
Ordered Locus Names:	HCH_04992

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

345

Dihydroorotase

PRO_1000024015

Sites

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1; via carbamate group By similarity

Metal binding

1

Zinc 2; via carbamate group By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 1 By similarity

Amino acid modifications

Modified residue

1

N6-carboxylysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q2SCE3-1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 25913E5A9141005F
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345

37,661

        10         20         30         40         50         60 
MSDLVITRPD DWHLHLRDGD ALATTVPATA RLFSRAIVMP NLVPPVTHTA QAEAYRHRIL 

        70         80         90        100        110        120 
SHVPAGAAFD PLMTLYLTNN TSPEEIVAAR QSGIVYGCKL YPAGATTNSD AGVTDVANVF 

       130        140        150        160        170        180 
SVLEKMSDMG MPLLIHGEVV QADVDIFDRE KRFIDETLTP LTERFPNLKI VLEHITTRDA 

       190        200        210        220        230        240 
VEFVNQAGSN VGATITAHHL LYNRNHMLVG GIRPHFYCLP ILKRSEHQLA LRDAAASGSD 

       250        260        270        280        290        300 
RFFLGTDSAP HPKEKKEAAC GCAGCFTAPS ALELYAEAFD ELGALDKLEG FASLHGPTFY 

       310        320        330        340 
GLPINSGKVR LSKQEWTMPA SMALGDSSIV PFRAGETIRW KAELL

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent."
Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F.
Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CP000155 Genomic DNA. Translation: ABC31681.1.
RefSeq	YP_436106.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3842977.
GenomeReviews	Gene locus HCH_04992 in contig CP000155_GR.
KEGG	hch:HCH_04992.
NMPDR	fig\|349521.5.peg.4382.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2SCE3.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_04992-MON.
Family and domain databases
HAMAP	MF_00219. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
PIRSF	PIRSF001237. DHOdimr. 1 hit.
TIGRFAMs	TIGR00856. pyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRC_HAHCH

Accession

Primary (citable) accession number: Q2SCE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents