Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei623ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HCH_05355
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
Proteomesi
  • UP000000238 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093511 – 861Leucine--tRNA ligaseAdd BLAST861

Interactioni

Protein-protein interaction databases

STRINGi349521.HCH_05355.

Structurei

3D structure databases

ProteinModelPortaliQ2SBE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi620 – 624"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHRFIKRL.
OrthoDBiPOG091H01JZ.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2SBE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELYHPKKV EQEAQKFWEE TDAFKVDEEP GKEKFYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMQG KNVLQPMGWD AFGLPAENAA LKNNVAPAKW
110 120 130 140 150
TYENIAYMKN QLKLLGFGYD WNRELATCRP EYYKWEQWFF TRLYEKGLVY
160 170 180 190 200
KKMSTVNWDP VDETVLANEQ VIDGKGWRSG AVVERREIPQ WFIKITDYAE
210 220 230 240 250
QLLNDLDKLE NWPEQVKTMQ RNWINKSEGV EFHFKLKDHD GDLQVYTTRP
260 270 280 290 300
DTIMGVTYVA IAPQHPLALE AAASNPQLAK FLDECKNTKV AEADMATMEK
310 320 330 340 350
RGMDTGFFVI HPLTNEPAPI WVANFVLMDY GSGAVMSVPG HDERDHEFAL
360 370 380 390 400
KYGLPIKQVI SVIDADEVDI QEKAITEKGI LVNSGEFTGM TSQEAFDAVA
410 420 430 440 450
EKLTAMGIGE KKINYRLRDW GVSRQRYWGA PIPMMTQEDG TEVPVPLADL
460 470 480 490 500
PVRLPEDVEM DGVKSPIKAD PNWSKRSYNG QPATQETDTF DTFMESSWYY
510 520 530 540 550
ARFCCPNLES AMLDPAAANY WLPVDYYVGG IEHAILHLLY SRFFHKLLRD
560 570 580 590 600
EGLVDSDEPF KKLLCQGMVI AETFYREDPS SKKTYFNPRD VRVELDTQGN
610 620 630 640 650
SPKAFLIEDG QPVIIGPKEK MSKSKNNGVD PQELIDKYGA DTVRLFTMFA
660 670 680 690 700
APPEQSLEWS ESGVEGQHRF LRRLWKLVHT HVEKKGAAPL NVAELNETQR
710 720 730 740 750
TLRRKTHETI KKMTDEFNHR MAINTGIAMV MELLNELSRF EDDSPQGLAV
760 770 780 790 800
VQEALETAVL VLAPIVPHIS HGLWRELGHE DVVMNAPWPQ LDEKALEKDS
810 820 830 840 850
IELVVQVNGK LRARIQAAAS ANKDELEKLA FDDENVQRFM EDKTVVKVIV
860
VPGKLVNIVV K
Length:861
Mass (Da):98,380
Last modified:January 24, 2006 - v1
Checksum:iF240E4CD127901D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC32027.1.
RefSeqiWP_011399091.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC32027; ABC32027; HCH_05355.
KEGGihch:HCH_05355.
PATRICi22091050. VBIHahChe29232_4876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000155 Genomic DNA. Translation: ABC32027.1.
RefSeqiWP_011399091.1. NC_007645.1.

3D structure databases

ProteinModelPortaliQ2SBE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349521.HCH_05355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC32027; ABC32027; HCH_05355.
KEGGihch:HCH_05355.
PATRICi22091050. VBIHahChe29232_4876.

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHRFIKRL.
OrthoDBiPOG091H01JZ.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_HAHCH
AccessioniPrimary (citable) accession number: Q2SBE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.