Q2SA27 (PROA_HAHCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	HCH_05847

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_0000252574

Sequences

	Sequence		Length	Mass (Da)
	Q2SA27 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: D7CB28C4980704C4	FASTA	418	44,631
	10 20 30 40 50 60 MDINAYMREV GSEARSASRL IAKADTGVKN KALIATAEAI DAAREELMAA NAKDLESGRA 70 80 90 100 110 120 NGLDAALLDR LELTPARIDA MIKGLHQVAA LPDPVGEITG LNYRPSGIQV GKMRVPLGVV 130 140 150 160 170 180 GIIYESRPNV TVEAASLCLK SGNATILRGG SEAIHSNQAI AACIENGLKT AGLPASVVQV 190 200 210 220 230 240 IKTTDRAAVG ELITMPDYVD VIVPRGGKGL IERISREARV PVIKHLDGVC HVFIDRDADL 250 260 270 280 290 300 NKALTIAVNS KTQRYGTCNT METLLVDAPV AATILPQLAQ AYAEKGVELR GCERTREILP 310 320 330 340 350 360 QALSAVEADW SEEYLAPILA IKVVENLDEA IAHINHYGSH HTDAIVTESY SKGRRFLTEV 370 380 390 400 410 DSSSVMINAS TRFADGFEYG LGAEIGISTD KIHARGPVGL EGLTSQKYVV LGDGHIRQ

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KCTC 2396.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000155 Genomic DNA. Translation: ABC32497.1.
RefSeq	YP_436922.1. NC_007645.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLU based on UniProtKB P54885.
ProteinModelPortal	Q2SA27.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2SA27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3843455.
GenomeReviews	Gene locus HCH_05847 in contig CP000155_GR.
KEGG	hch:HCH_05847.
NMPDR	fig|349521.5.peg.5117.
PATRIC	22091914. VBIHahChe29232_5302.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0014.
HOGENOM	HBG318080.
OMA	YGICGAM.
PhylomeDB	Q2SA27.
ProtClustDB	PRK00197.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_05847-MONOMER.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_HAHCH

Accession

Primary (citable) accession number: Q2SA27

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program