Reviewed, UniProtKB/Swiss-Prot Q2S9R4 (GLYA2_HAHCH)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 2
      Short name=Serine methylase 2
      Short name=SHMT 2
    EC=2.1.2.1

Gene names

Name:	glyA2
Ordered Locus Names:	HCH_05959

Organism

Hahella chejuensis (strain KCTC 2396) [Complete proteome] [HAMAP]

Taxonomic identifier

349521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Hahellaceae › Hahella

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Serine hydroxymethyltransferase 2 HAMAP MF_00051		PRO_0000234982
Amino acid modifications
	Modified residue	230	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2S9R4-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: D2AD9550FD1F30C9	FASTA	418	45,889
	10 20 30 40 50 60 MFTRDMTIAS FDPDLWTAMQ GETQRQEEHI ELIASENYTS PRVMEAQGSA LTNKYAEGYP 70 80 90 100 110 120 NKRYYGGCEY VDVVEQLAID RAKELFGADY ANVQPHSGSQ ANAAVYMALC KPGDVILGMS 130 140 150 160 170 180 LAHGGHLTHG ASVSFSGRIY KAVQYGLNPE TGEIDYEEVA KLARENKPKM IVAGFSAYSR 190 200 210 220 230 240 VIDWERFRAI ADEVGAYLFV DMAHIAGLVA AGVYPSPVQI ADVTTTTTHK TLGGPRGGLI 250 260 270 280 290 300 LAKANEELEK KLNFAVFPES QGGPLMHVIA AKAVCFKEAM TDEFKQYQAQ VVKNARVMAD 310 320 330 340 350 360 TFIQRGYDIV SGGTDDHLFL VDLIKKDITG KDADAALGRA NITVNKNAVP NDPRSPFVTS 370 380 390 400 410 GLRIGTPAIT RRGMGEVEAK ELTDWICDVL DDIENEETIQ RVKQQVLELC KKFPVYKG

References

[1]

"Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent." Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G., Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K., Oh T.K., Kim J.F. Nucleic Acids Res. 33:7066-7073(2005) [PubMed: 16352867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000155 Genomic DNA. Translation: ABC32610.1.
RefSeq	YP_437035.1.
3D structure databases
SMR	Q2S9R4. Positions 1-416.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2S9R4.
Genome annotation databases
GeneID	3838637.
GenomeReviews	Gene locus HCH_05959 in contig CP000155_GR.
KEGG	hch:HCH_05959.
NMPDR	fig|349521.5.peg.5219.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2S9R4.
OMA	MEAMGSL.
Enzyme and pathway databases
BioCyc	HCHE349521:HCH_05959-MON.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA2_HAHCH

Accession

Primary (citable) accession number: Q2S9R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	January 24, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)